{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:32:17Z","timestamp":1783632737957,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Adrenocortical carcinoma is a rare condition, with limited comprehensive reports from Japan. This study aimed to review Japan's data on adrenocortical carcinoma by assessing information from 46 patients\u2014with adrenocortical carcinoma across 10 Japanese university hospitals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective multi\u2010institutional analysis of the clinical characteristics of adrenocortical carcinoma in Japan. We evaluated data from 46 patients across 10 university hospitals over 10\u2009years and analyzed the relationship between clinicopathological characteristics and overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five\u2010 and 10\u2010year overall survival rates were 59% and 53%, respectively. Overall survival was significantly different among the tumor\u2013node\u2013metastasis system for adrenocortical carcinoma of the American Joint Committee on Cancer\/International Union Against Cancer, with the worst prognosis in stage IV (<jats:italic>p<\/jats:italic>\u2009=\u20090.0044). In our cohort, neither the Weiss score nor the Ki\u201067 proliferation index correlated with overall survival. Adjuvant treatment did not yield improved overall survival, whereas resection of the primary tumor in stage IV disease was significantly associated with improved overall survival (<jats:italic>p<\/jats:italic>\u2009=\u20090.0262). Out of the cases evaluated for plasma hormones, plasma cortisol, aldosterone, testosterone, and DHEA\u2010S levels were measured at 23%, 42%, 29%, and 62%, respectively, demonstrating higher levels than the upper normal limits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with stage IV adrenocortical carcinoma had a poor prognosis; however, resection of the primary tumor in stage IV disease was associated with prolonged survival. The results of this study are expected to contribute to future treatment of adrenocortical carcinoma in Japan.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.15386","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T12:25:08Z","timestamp":1704803108000},"page":"484-491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinicopathological characteristics of adrenocortical carcinoma in the <scp>Kyushu\u2013Okinawa<\/scp> area of Japan"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0117-9490","authenticated-orcid":false,"given":"Shotaro","family":"Nakanishi","sequence":"first","affiliation":[{"name":"Department of Urology, Graduate School of Medicine University of the Ryukyus  Nishihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumi","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Life Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Inokuchi","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Hakariya","sequence":"additional","affiliation":[{"name":"Department of Urology Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Kakinoki","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medicine Saga University  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Enokida","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medicine Kagoshima University  Kagoshima 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