{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:10:57Z","timestamp":1791389457869,"version":"4.3.3"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:00:00Z","timestamp":1705622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Previous studies suggested that living kidney donors do not have a higher risk of death or kidney failure than the general population. However, living kidney donor risk is controversial. Furthermore, only a few studies have evaluated long\u2010term kidney function after kidney donation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study evaluated Japanese kidney donor' long\u2010term outcomes, including mortality and kidney function. From 1965 to 2015, 230 donors (76 males, 154 females, and a median age of 54) were enrolled in this study. The median observation period was 11.0 (range, 0.3\u201341.0) years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 215 donors were still alive, and 15 had died. Causes of death included malignancies, cardiovascular disease, pneumonia, suicide, gastrointestinal bleeding, and kidney failure. Actual donor survival rates at 10, 20, and 30\u2009years were 95.3%, 90.7%, and 80.9%, respectively. These values were comparable to age\u2010 and gender\u2010matched expected survival. Long\u2010term kidney function after donation was evaluated in 211 donors with serum creatinine data. Two donors developed kidney failure 24 and 26\u2009years post\u2010donation, respectively. The percentage of donors whose estimated glomerular filtration rate (eGFR) remained \u226545\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup> at 10, 20, and 30\u2009years after donation were 84.2%, 73.0%, and 63.9%, respectively. Survival rates of donors with eGFR &lt;45\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup> were comparable to those in persons with eGFR &gt;45\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings revealed that kidney donors did not have a higher long\u2010term risk of death than the general population. Although some donors showed decreased kidney function after donation, kidney function did not impact their survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.15395","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T10:23:30Z","timestamp":1705659810000},"page":"519-524","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Longitudinal mortality risks and kidney functional outcomes in Japanese living kidney donors"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7950-0961","authenticated-orcid":false,"given":"Takayuki","family":"Hirose","sequence":"first","affiliation":[{"name":"Department of Urology Hokkaido University Hospital  Sapporo Hokkaido 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