{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:46:33Z","timestamp":1772160393969,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:00:00Z","timestamp":1710201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004847","name":"Zahedan University of Medical Sciences","doi-asserted-by":"publisher","award":["9799"],"award-info":[{"award-number":["9799"]}],"id":[{"id":"10.13039\/501100004847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Infertility is inability to conceive after 12\u2009months of regular unprotected sex. MiRNA expression changes can serve as potential biomarkers for infertility in males due to impaired spermatogenesis. This research was conducted to measure the expression level of miR\u2010211 in plasma samples as a factor identifying infertility in comparison with the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this study, blood plasma were taken from the infertile men (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009103) nonobstructive azoospermia (NOA) or severe oligozoospermia (SO) and the control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009121). The expression of circulating miR\u2010211 in plasma was assessed by qRT\u2010PCR. A relative quantification strategy was adopted using the 2\n                      <jats:sup>\u2212\u0394\u0394CT<\/jats:sup>\n                      method to calculate the target miR\u2010211 expression level in both study groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Plasma miR\u2010211 levels were significantly lower in infertile men compared to the control group (0.544\u2009\u00b1\u20090.028 and 1.203\u2009\u00b1\u20090.035, respectively,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Pearson's correlation analysis showed that miR\u2010211 expression level has a positive and significant correlation with sperm parameters, including sperm concentration, sperm total motility, progressive motility, and normal morphology (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Decreased expression of miR\u2010211 in blood plasma seems to be associated with male infertility. This experiment showed that miR\u2010211 can be considered as a biomarker for evaluation, diagnosis, and confirmation of the results of semen analysis in male infertility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.15445","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T09:09:30Z","timestamp":1710234570000},"page":"718-723","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Downregulation of\n                    <scp>miR<\/scp>\n                    \u2010211 expression in the blood plasma of infertile men compared to the fertile controls"],"prefix":"10.1111","volume":"31","author":[{"given":"Nasim","family":"Naeimi","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Science University of Sistan and Baluchestan  Zahedan 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