{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T03:15:47Z","timestamp":1783221347069,"version":"3.54.6"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:00:00Z","timestamp":1710201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the utility of magnetic resonance imaging (MRI) and MRI\u2010ultrasound fusion targeted biopsy (TB) for predicting unexpected extracapsular extension (ECE) in clinically localized prostate cancer (CLPC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study enrolled 89 prostate cancer patients with one or more lesions showing a Prostate Imaging\u2010Reporting and Data System (PI\u2010RADS) score \u22653 but without morphological abnormality in the prostatic capsule on pre\u2010biopsy MRI. All patients underwent TB and systematic biopsy followed by radical prostatectomy (RP). Each lesion was examined by 3\u2010core TB, taking cores from each third of the lesion. The preoperative variables predictive of ECE were explored by referring to RP specimens in the lesion\u2010based analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 186 lesions, including 81 (43.5%), 73 (39.2%), and 32 (17.2%) with PI\u2010RADS 3, 4, and 5, respectively, were analyzed. One hundred and twenty\u2010two lesions (65.6%) were diagnosed as cancer on TB, and ECE was identified in 33 (17.7%) on the RP specimens. The positive TB core number was \u22642 in 129 lesions (69.4%) and three in 57 lesions (30.6%). On the multivariate analysis, PI\u2010RADS \u22654 (<jats:italic>p<\/jats:italic>\u2009=\u20090.049, odds ratio [OR]\u2009=\u20092.39) and three positive cores on TB (<jats:italic>p<\/jats:italic>\u2009=\u20090.005, OR\u2009=\u20093.07) were independent predictors of ECE. Lesions with PI\u2010RADS \u22654 and a positive TB core number of 3 had a significantly higher rate of ECE than those with PI\u2010RADS 3 and a positive TB core number \u22642 (37.5% vs. 7.8%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Positive TB core number in combination with PI\u2010RADS scores is helpful to predict unexpected ECE in CLPC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.15451","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T07:05:17Z","timestamp":1710227117000},"page":"739-746","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Utility of positive core number on <scp>MRI<\/scp>\u2010ultrasound fusion targeted biopsy in combination with <scp>PI\u2010RADS<\/scp> scores for predicting unexpected extracapsular extension of clinically localized prostate cancer"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2738-9792","authenticated-orcid":false,"given":"Masaki","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Department of Urology Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2440-5104","authenticated-orcid":false,"given":"Yoh","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Medical and Dental University  Tokyo Japan"},{"name":"Department of Urology Saitama Cancer Center  Ina Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Uehara","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of 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