{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T20:24:37Z","timestamp":1769286277275,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K20159"],"award-info":[{"award-number":["16K20159"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26861290"],"award-info":[{"award-number":["26861290"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K08720"],"award-info":[{"award-number":["23K08720"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to compare clinical outcomes between patients receiving second TUR after initial white\u2010light transurethral resection of bladder tumor (WL\u2010TURBT) and initial photodynamic diagnosis (PDD)\u2010assisted TURBT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1007 patients were divided into four groups based on the treatment pattern: WL\u2010TURBT with second TUR (161 patients, WL\u2010second group) or without second TUR (540 patients, WL\u2010alone group) and PDD\u2010TURBT with second TUR (112 patients, PDD\u2010second group) or without second TUR (194 patients, PDD\u2010alone group). Oncologic outcomes (bladder cancer recurrence, progression, urothelial cancer\u2010specific mortality) and rates of residual tumor and risk stratification of non\u2010muscle\u2010invasive bladder cancer (NMIBC) after second TUR were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After propensity score\u2010matching 121 patients were included each in the WL\u2010alone and WL\u2010second groups, and 63 patients each in the PDD\u2010alone and PDD\u2010second groups. In the WL group, the second TUR was significantly associated with improved progression\u2010free (<jats:italic>p<\/jats:italic> = 0.012) and urothelial cancer\u2010specific free survival (<jats:italic>p<\/jats:italic> = 0.011), but not with recurrence\u2010free survival (<jats:italic>p<\/jats:italic>\u2009=\u20090.93). Patients initially treated with PDD\u2010TURBT, and with a tumor diameter &lt;30\u2009mm and multifocality had a relatively high benefit from second TUR. The rates of residual tumor and risk stratification of NMIBC did not significantly differ between WL\u2010TURBT and PDD\u2010TURBT groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggested that a second TUR could be omitted after an initial PDD\u2010TURBT in selected patients with high\u2010risk NMIBC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.15474","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T13:40:31Z","timestamp":1714484431000},"page":"876-885","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Differences in oncological benefits from second transurethral resection between white\u2010light initial surgery and photodynamic diagnosis\u2010guided initial surgery for primary high\u2010risk non\u2010muscle invasive bladder cancer"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9503-7356","authenticated-orcid":false,"given":"Makito","family":"Miyake","sequence":"first","affiliation":[{"name":"Department of Urology Nara Medical University  Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobutaka","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Urology Nara Medical University  Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomonori","family":"Nakahama","sequence":"additional","affiliation":[{"name":"Department of Urology Nara Medical University  Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koshiro","family":"Nishimoto","sequence":"additional","affiliation":[{"name":"Department of Uro\u2010Oncology Saitama Medical University International Medical Center  Hidaka Japan"},{"name":"Department of Urology, Faculty of Medicine University of Miyazaki  Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Oyama","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medicine University of Miyazaki  Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8159-9793","authenticated-orcid":false,"given":"Yuto","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Urology Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Miyake","sequence":"additional","affiliation":[{"name":"Department of Urology Hamamatsu University School of Medicine  Hamamatsu Japan"},{"name":"Division of Urology Kobe University Graduate School of Medicine  Kobe 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