{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:18:51Z","timestamp":1792729131386,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Intraoperative hypotension remains a serious adverse event of photodynamic diagnosis\u2010assisted transurethral resection of bladder tumor with oral administration of 5\u2010aminolevulinic acid. We conducted a re\u2010analysis of perioperative hypotension in photodynamic diagnosis\u2010assisted transurethral resection of the bladder tumor with oral 5\u2010aminolevulinic acid to ascertain its safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 407 cases who underwent transurethral resection of bladder tumors in our institution were reviewed (274 cases for the PDD group with photodynamic diagnosis and 133 for the white light (WL) group without). A classification of hypotension severity was devised to identify risk factors for clinically troublesome hypotension. The distribution of hypotension severity in each of the PDD and WL groups was compared. Additionally, the patient background and perioperative data by hypotension severity were compared only in the PDD group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>More patients with moderate and severe hypotension were noted in the PDD group. The renal function was lower with increasing hypotension severity in the PDD group. More patients on general anesthesia were included in the mild and moderate hypotension group, whereas more patients on spinal anesthesia were included in the severe hypotension group. Furthermore, the frequency of side effects other than hypotension tended to increase with hypotension severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Renal function impairment and the other adverse effects of 5\u2010aminolevulinic acid may be risk factors for severe hypotension. Mild or moderate hypotension may be caused by general anesthesia and severe hypotension may be caused by spinal anesthesia. To elucidate specific risk factors, further case\u2013control studies are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.15477","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T13:13:34Z","timestamp":1714482814000},"page":"891-898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Comprehensive analysis of perioperative hypotension in photodynamic diagnosis\u2010assisted transurethral resection of bladder tumor with <scp>5\u2010aminolevulinic<\/scp> acid"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9792-2068","authenticated-orcid":false,"given":"Takahiro","family":"Nohara","sequence":"first","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology Kanazawa University  Kanazawa Ishikawa 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