{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T03:05:31Z","timestamp":1781579131024,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010795","name":"Chugai Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>In a primary analysis of data from the BRIGHT study (UMIN000035712), photodynamic diagnosis\u2010assisted transurethral resection of bladder tumor (PDD\u2010TURBT) using oral 5\u2010aminolevulinic acid hydrochloride reduced residual tumors in high\u2010risk non\u2010muscle invasive bladder cancer (NMIBC). We aimed to evaluate the effectiveness of PDD\u2010TURBT for intravesical recurrence after a second transurethral resection for high\u2010risk NMIBC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>High\u2010risk NMIBC patients initially treated with PDD\u2010TURBT (PDD group) were prospectively registered between 2018 and 2020. High\u2010risk patients with NMIBC who were initially treated with white\u2010light TURBT (WL group) were retrospectively registered. Intravesical recurrence\u2010free survival after the second transurethral resection was compared between the PDD and WL groups using propensity score matching analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 177 patients were enrolled in the PDD group, and 306 patients were registered in the WL group. After propensity score matching (146 cases in each group), intravesical recurrence within 1\u2009year was significantly less frequent in the PDD group than in the WL group (<jats:italic>p<\/jats:italic>\u2009=\u20090.004; hazard ratio [HR] 0.44, 95% confidence interval [CI]: 0.25\u20130.77). In subgroup analysis, PDD\u2010TURBT showed a particularly high efficacy in reducing intravesical recurrence within 1\u2009year, especially in cases of tumors measuring less than 3\u2009cm (<jats:italic>p<\/jats:italic>\u2009=\u20090.003; HR 0.31, 95% CI: 0.14\u20130.67), absence of residual tumor at second transurethral resection (<jats:italic>p<\/jats:italic>\u2009=\u20090.020; HR 0.37, 95% CI: 0.16\u20130.86), and no postoperative intravesical Bacillus Calmette\u2010Gu\u00e9rin therapy (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; HR 0.27, 95% CI: 0.13\u20130.58).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PDD\u2010TURBT may reduce short\u2010term intravesical recurrence in patients with high\u2010risk NMIBC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.15483","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T12:59:45Z","timestamp":1714654785000},"page":"906-912","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Photodynamic diagnosis\u2010assisted transurethral resection of bladder tumor for high\u2010risk non\u2010muscle invasive bladder cancer improves intravesical recurrence\u2010free survival (BRIGHT study)"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7279-2874","authenticated-orcid":false,"given":"Taketo","family":"Kawai","sequence":"first","affiliation":[{"name":"Department of Urology Teikyo University School of Medicine  Tokyo Japan"},{"name":"Department of Urology, Graduate School of Medicine The University of Tokyo  Tokyo 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Urology Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhito","family":"Azuma","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka Medical and Pharmaceutical University Faculty of Medicine  Takatsuki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Urology Kochi Medical School  Nankoku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0408-3678","authenticated-orcid":false,"given":"Takahiko","family":"Mitsui","sequence":"additional","affiliation":[{"name":"Department of Urology University of Yamanashi Graduate School of Medical Sciences  Chuo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutsushi","family":"Kawakita","sequence":"additional","affiliation":[{"name":"Department of Urology Kobe City Medical 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