{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T06:04:34Z","timestamp":1780553074472,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the efficacy and safety of dose\u2010dense methotrexate, vinblastine, doxorubicin, and cisplatin (dd\u2010MVAC) with gemcitabine\u2010based regimens for neoadjuvant chemotherapy (NAC) in muscle\u2010invasive bladder cancer (MIBC) patients treated in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data for MIBC patients who received NAC\u2010dd\u2010MVAC followed by a radical cystectomy from June 2019 to May 2023 performed at our hospital were analyzed. For comparisons, data for MIBC patients who received NAC gemcitabine and cisplatin (GC) or gemcitabine and carboplatin (GCarbo) therapy between January 2010 and March 2019 were also obtained. Rates of ypT1N0 or less, progression\u2010free survival (PFS), overall survival (OS), and NAC adverse effects were compared between the GC\/GCarbo and dd\u2010MVAC regimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Results for 32 patients who received dd\u2010MVAC and 30 who received GC\/GCarbo NAC therapy were analyzed. ypT1N0 or less was noted in 40.7% of the dd\u2010MVAC and 40.0% of the GC\/GCarbo groups, while ypT0N0 rates were 25% and 10%, respectively, with no statistical differences noted. However, Kaplan\u2013Meier analysis of the total cohort demonstrated that dd\u2010MVAC was associated with significantly better PFS and OS rates than GG\/GCarbo (hazard ratios: 0.33, <jats:italic>p<\/jats:italic>\u2009=\u20090.0237, and 0.23, <jats:italic>p<\/jats:italic>\u2009=\u20090.0127, respectively). Propensity\u2010matched models also showed similar results for both PFS and OS. Adverse effects of dd\u2010MVAC were acceptable and the incidence of hematologic toxicity was lower as compared with GC\/GCarbo therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study is the first to show that dd\u2010MVAC as NAC can provide better survival as compared with a gemcitabine\u2010based regimen for patients with MIBC treated in Japan.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.15509","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T12:02:33Z","timestamp":1717156953000},"page":"1030-1037","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effectiveness of dose\u2010dense methotrexate, vinblastine, doxorubicin, and cisplatin as compared to gemcitabine\u2010based regimens as neoadjuvant chemotherapy for oncologic outcomes in muscle\u2010invasive bladder cancer cases\u2014Single\u2010center study in Japan"],"prefix":"10.1111","volume":"31","author":[{"given":"Yozo","family":"Mitsui","sequence":"first","affiliation":[{"name":"Department of Urology Toho University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuho","family":"Okawa","sequence":"additional","affiliation":[{"name":"Department of Urology Toho University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Hori","sequence":"additional","affiliation":[{"name":"Department of Urology Toho University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Uetani","sequence":"additional","affiliation":[{"name":"Department of Urology Toho University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuki","family":"Kasahara","sequence":"additional","affiliation":[{"name":"Department of Urology Toho University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumito","family":"Yamabe","sequence":"additional","affiliation":[{"name":"Department of Urology Toho University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Urology Toho University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Nagao","sequence":"additional","affiliation":[{"name":"Department of Urology Toho University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Urology Toho University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,31]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562872221134389"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60491-8"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22137201"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2020.02.014"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.05.101"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu126"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29387"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2011.10.050"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyy122"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.08.032"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.52.4785"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.2465"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-017-2065-x"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.3542"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02051"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(23)00587-9"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_12_20_1","unstructured":"NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae).Bladder cancer V1.2024. 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