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However, transurethral procedures are associated with high recurrence rates, resulting in many uncured cases and prompting major international urological societies to recommend urethroplasty as the standard treatment owing to its high success rate. In contrast, many Japanese general urologists have little doubts about treating urethral strictures with transurethral treatment. Therefore, urethral stricture treatments in Japan are not in line with those used in other countries. To address this, the Trauma, Emergency Medicine, and Reconstruction Subcommittee of the Japanese Urological Association has developed guidelines to offer standardized treatment protocols for urethral stricture, based on international evidence and tailored to Japan's medical landscape. These guidelines target patients with a clinically suspected urethral stricture and are intended for urologists and general practitioners involved in its diagnosis and treatment. Following the Minds Clinical Practice Guideline Development Manual 2020, the committee identified eight critical clinical issues and formulated eight clinical questions using the \u201cpatient, intervention, comparison, and outcome\u201d format. A comprehensive literature search was conducted. For six clinical questions addressed by the existing guidelines or systematic reviews, the level of evidence was determined by qualitative systematic reviews. Quantitative systematic reviews and meta\u2010analyses were performed for the two unique clinical questions. The recommendation grades were determined using the Delphi method and consensus by the committee. These guidelines will be useful to clinicians in daily practice, especially those involved in the care of urethral strictures.<\/jats:p>","DOI":"10.1111\/iju.15512","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T13:06:54Z","timestamp":1718370414000},"page":"956-967","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical questions in the Japanese Urological Association's 2024 clinical practice guidelines for urethral strictures"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7678-6375","authenticated-orcid":false,"given":"Akio","family":"Horiguchi","sequence":"first","affiliation":[{"name":"Department of Urology National Defense Medical College  Tokorozawa Saitama Japan"},{"name":"Division of Trauma Reconstruction National Defense Medical College  Tokorozawa Saitama 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