{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:44:31Z","timestamp":1792619071603,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Desmopressin improves nocturia frequency; however, reports on its long\u2010term efficacy and safety are few, and concerns regarding its effect on body composition exist. We thus investigated the efficacy and safety of long\u2010term desmopressin administration and its effect on body composition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study, conducted at Chikugo City Hospital between August 2020 and December 2022, involved 133 men (mean age, 77.7\u2009years) with nocturnal and persistent nocturia, who were administered an initial dose of 50\u2009\u03bcg desmopressin. Efficacy endpoints included nocturnal urinary frequency, nocturnal urinary volume, hours of undisturbed sleep, nocturnal polyuria index, initial nocturnal urinary volume, and daily urinary frequency in a frequency\u2010volume chart (3\u2009days), before treatment and at 1, 4, 12, 24, and 52\u2009weeks after desmopressin administration. Additionally, the effects of desmopressin on body composition were examined, including blood\u2013brain natriuretic peptide and a chest radiography, before and 52\u2009weeks after administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment improved most efficacy endpoint evaluation parameters. Around 87.6% of patients showed improved symptoms after 52\u2009weeks compared with those before treatment (score\u2009\u2264\u20093). The blood\u2013brain natriuretic peptide level rose; however, cardiothoracic ratio was unchanged.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Long\u2010term administration of desmopressin is thus effective and safe in older people with nocturnal polyuria, with little effect on body composition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.15530","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T12:28:18Z","timestamp":1721046498000},"page":"1114-1120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of long\u2010term desmopressin treatment for nocturia in older people"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0395-9490","authenticated-orcid":false,"given":"Hirofumi","family":"Kurose","sequence":"first","affiliation":[{"name":"Department of Urology Chikugo City Hospital  Chikugo Fukoka 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