{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T08:14:14Z","timestamp":1783152854650,"version":"3.54.6"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2024JDHJ0045"],"award-info":[{"award-number":["2024JDHJ0045"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The effectiveness of docetaxel in addition to next\u2010generation androgen receptor\u2010axis\u2010targeted therapies and androgen deprivation therapy (ADT) for metastatic hormone\u2010sensitive prostate cancer (mHSPC) remains unclear. We evaluated the efficacy of this combination through tumor volume\u2010specific analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Individual patient data were reconstructed from seven clinical trials focusing mHSPC (ARASENS, PEACE\u20101, TITAN, ENZAMET, ARCHES, STAMPEDE, and LATITUDE) through the Shiny method. Overall survival (OS), radiological progression\u2010free survival (rPFS), and time to castration\u2010resistant prostate cancer (CRPC) were analyzed in the overall cohort and tumor volume\u2010specific (high\/low) subgroups. Sensitivity analyses were performed based on treatment methods and metastasis onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 6931 cases, adding docetaxel to ARAT and ADT did not significantly improve OS (hazard ratio [HR]\u2009=\u20091.07, 95% confidence interval [CI]: 0.95\u20131.22, <jats:italic>p<\/jats:italic>\u2009=\u20090.27), rPFS (HR\u2009=\u20090.88, 95% CI: 0.73\u20131.05, <jats:italic>p<\/jats:italic>\u2009=\u20090.16), or time to CRPC (HR\u2009=\u20090.97, 95% CI: 0.80\u20131.18, <jats:italic>p<\/jats:italic>\u2009=\u20090.74). High\u2010volume disease showed a non\u2010significant trend toward improved OS with the triplet regimen. Low\u2010volume disease showed a similar trend. Sensitivity analyses for second\u2010generation androgen receptor inhibitors indicated potentially less advantageous OS with docetaxel addition, but no significant differences when stratified by tumor volume. Analyses of the docetaxel\u2010na\u00efve, abiraterone, and synchronous metastasis subgroups showed no statistically significant differences in OS compared with the overall population and volume\u2010stratified cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with mHSPC did not show significant improvement with docetaxel addition to ARAT\u2010based regimens, regardless of tumor volume. Further research is needed to identify potential beneficiaries of this combination therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.15657","type":"journal-article","created":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T07:45:17Z","timestamp":1734767117000},"page":"361-370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Efficacy of docetaxel addition to next\u2010generation androgen receptor\u2010axis\u2010targeted therapies and androgen deprivation therapy in metastatic hormone\u2010sensitive prostate cancer: A tumor volume\u2010specific analysis"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2275-4527","authenticated-orcid":false,"given":"Wei","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Urology Institute of Science Tokyo  Tokyo Japan"},{"name":"Department of Urology Zigong Fourth People's Hospital  Zigong Sichuan 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