{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T10:37:23Z","timestamp":1780742243690,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Radical prostatectomy (RP) may be a treatment option for prostate cancer in patients with chronic kidney disease (CKD). However, the effect of CKD on adverse in\u2010hospital outcomes after RP is not well known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Descriptive analyses, propensity score matching (PSM), and multivariable logistic and Poisson regression models were used to address National Inpatient Sample RP patients between 2005 and 2019. CKD severity was stratified as mild (stage I\/II) versus moderate (stage III) versus severe (stage IV\/V).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 191\u2009050 RP patients, 4349 (2.3%) had CKD. Of those, 2301 (52.9%), 1416 (32.6%), and 632 (14.5%) were classified as mild, moderate, or severe CKD, respectively. The CKD rate increased from 0.3% to 5.6% (2005\u20132019, EAPC: +\u200915.3%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). CKD patients invariably exhibited higher rates of adverse in\u2010hospital outcomes, except for in\u2010hospital mortality. The absolute differences were largest for overall complications (+\u200912.5%), length of stay &gt;\u20092\u2009days (+\u200911.8%), and blood transfusions (+\u20093.7%, all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). CKD was an independent predictor in all comparisons except for in\u2010hospital mortality (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The detrimental effect was most pronounced for dialysis for acute kidney failure (multivariable odds ratio [OR] 10.49), genitourinary complications (OR: 2.47), and critical care therapies (OR: 2.45, all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Finally, a dose\u2013response relationship of CKD severity (mild vs. moderate vs. severe) and its effect on adverse in\u2010hospital outcomes was observed in seven of 14 comparisons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CKD patients invariably exhibited higher rates of adverse in\u2010hospital outcomes after RP. The presence of CKD should be carefully considered when RP represents a management option.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.70038","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T12:10:04Z","timestamp":1741954204000},"page":"710-717","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Effect of Chronic Kidney Disease on Adverse In\u2010Hospital Outcomes at Radical Prostatectomy"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1907-3982","authenticated-orcid":false,"given":"Fabian","family":"Falkenbach","sequence":"first","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Martini\u2010Klinik Prostate Cancer Center University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natali Rodriguez","family":"Pe\u00f1aranda","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Urology Ospedale Policlinico e Nuovo Ospedale Civile S. Agostino Estense Modena, University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Longoni","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Marmiroli","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Urology IEO European Institute of Oncology, IRCCS  Milan Italy"},{"name":"Department of Oncology and Haemato\u2010Oncology Universit\u00e0 degli Studi di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quynh Chi","family":"Le","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Urology Goethe University Frankfurt, University Hospital  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calogero","family":"Catanzaro","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Division of Urology IRCCS Azienda Ospedaliero\u2010universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7773-5101","authenticated-orcid":false,"given":"Michele","family":"Nicolazzini","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Division of Urology, Department of Translational Medicine University of Eastern Piedmont, Maggiore della Carit\u00e0 Hospital  Novara Italy"},{"name":"Division of Urology, Department of Oncology University of Turin  Orbassano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Tian","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan A.","family":"Goyal","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Puliatti","sequence":"additional","affiliation":[{"name":"Department of Urology Ospedale Policlinico e Nuovo Ospedale Civile S. 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