{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T22:31:22Z","timestamp":1775082682783,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the outcomes of the second transurethral resection of bladder tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with bladder cancer who accepted both initial and second resections in our center from January 2021 to March 2024 were included. Tumor residue in the second resection and short\u2010term oncological outcomes were determined. Multivariate analysis was performed to identify predictive factors for them.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 125 patients were included. Tumor residue and upstaging were confirmed in 15 (12%) and in 1 (0.8%) patient, respectively. A younger age and a longer time (&gt;\u20096w) to second resection were associated with a higher tumor residual rate (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), and they were confirmed as predictors for tumor residue. Differences were not determined between patients with different tumor characteristics (e.g., Ta vs. T1). A median follow\u2010up of 14 (3\u201340) months was conducted in 100 patients. Intravesical recurrence and progression were determined in 14 (14%) and 4 (4%) patients, with the 1\u2010year recurrence\u2010free and progression\u2010free survivals of 86.5% and 96.9%, respectively. Maintenance BCG therapy was identified as a predictor for tumor recurrence (HR\u2009=\u20096.168, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A lower tumor residual rate than previously reported was achieved with acceptable short\u2010term oncological outcomes after conventional transurethral resection of bladder tumors. The basis of second resection may need further exploration. Second resection may be prioritized for younger patients and performed within 6\u2009weeks of the initial resection. Maintenance BCG therapy could reduce tumor recurrence after second resection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.70041","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T16:54:20Z","timestamp":1741625660000},"page":"720-726","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Outcomes of Second Resection Following Conventional Initial Transurethral Resection of Bladder Tumors"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9284-0711","authenticated-orcid":false,"given":"Song","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Urology Zhongnan Hospital of Wuhan University  Wuhan China"},{"name":"Institute of Urology Wuhan University  Wuhan China"},{"name":"Hubei Key Laboratory of Urological Diseases  Wuhan China"},{"name":"Hubei Clinical Research Center for Laparoscopic\/Endoscopic Urologic Surgery  Wuhan China"},{"name":"Hubei Medical Quality Control Center for Laparoscopic\/Endoscopic Urologic Surgery  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongjie","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Biological Repositories, Human Genetic Resources Preservation Center of Hubei Province Zhongnan Hospital of Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pathology Zhongnan Hospital of Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengxin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Urology Zhongnan Hospital of Wuhan University  Wuhan China"},{"name":"Institute of Urology Wuhan University  Wuhan China"},{"name":"Hubei Key Laboratory of Urological Diseases  Wuhan China"},{"name":"Hubei Clinical Research Center for Laparoscopic\/Endoscopic Urologic Surgery  Wuhan China"},{"name":"Hubei Medical Quality Control Center for Laparoscopic\/Endoscopic Urologic Surgery  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhonghua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology Zhongnan Hospital of Wuhan University  Wuhan China"},{"name":"Institute of Urology Wuhan University  Wuhan China"},{"name":"Hubei Key Laboratory of Urological Diseases  Wuhan China"},{"name":"Hubei Clinical Research Center for Laparoscopic\/Endoscopic Urologic Surgery  Wuhan China"},{"name":"Hubei Medical Quality Control Center for Laparoscopic\/Endoscopic Urologic Surgery  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Urology Zhongnan Hospital of Wuhan University  Wuhan China"},{"name":"Institute of Urology Wuhan University  Wuhan China"},{"name":"Hubei Key Laboratory of Urological Diseases  Wuhan China"},{"name":"Hubei Clinical Research Center for Laparoscopic\/Endoscopic Urologic Surgery  Wuhan China"},{"name":"Hubei Medical Quality Control Center for Laparoscopic\/Endoscopic Urologic Surgery  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11175049"},{"key":"e_1_2_10_3_1","unstructured":"European Association of Urology \u201cEAU Guidelines on Non\u2010Muscle\u2010Invasive Bladder Cancer (TaT1 and CIS) \u201dhttps:\/\/d56bochluxqnz.cloudfront.net\/documents\/full\u2010guideline\/EAU\u2010Guidelines\u2010on\u2010Non\u2010muscle\u2010Invasive\u2010Bladder\u2010Cancer\u20102024.pdf."},{"key":"e_1_2_10_4_1","unstructured":"American Urological Association \u201cDiagnosis and Treatment of Non\u2010Muscle Invasive Bladder Cancer: AUA\/SUO Guideline \u201dhttps:\/\/www.auanet.org\/guidelines\u2010and\u2010quality\/guidelines\/oncology\u2010guidelines."},{"key":"e_1_2_10_5_1","unstructured":"National Comprehensive Cancer Network \u201cNCCN Clinical Practice Guidelines in Oncology: Bladder Cancer \u201dhttps:\/\/www.nccn.org\/guidelines\/guidelines\u2010detail?category=1&id=1417."},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2023.07.002"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147\u2010019\u201001581\u20100"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2022.06.005"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.15622"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.02.014"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0302\u20102838(02)00068\u20104"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345\u2010020\u201003313\u2010w"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345\u2010023\u201004469\u2010x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9103306"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13102"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2020.1107"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000491642"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acuroe.2022.05.001"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.04.066"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000181799.81119.fc"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2021.02.009"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13354"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/21681805.2021.1892179"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974\u20107796.163798"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345\u2010018\u20102299\u20102"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.1514"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2017.10.004"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.14761"}],"container-title":["International Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.70041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T03:03:13Z","timestamp":1749438193000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iju.70041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,10]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/iju.70041"],"URL":"https:\/\/doi.org\/10.1111\/iju.70041","archive":["Portico"],"relation":{},"ISSN":["0919-8172","1442-2042"],"issn-type":[{"value":"0919-8172","type":"print"},{"value":"1442-2042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,10]]},"assertion":[{"value":"2024-11-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}