{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:14:03Z","timestamp":1792106043779,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Testicular torsion is a urological emergency with a risk of resulting in loss of testicular function due to ischemia\/reperfusion injury (I\/R) injury caused by oxidative stress. <jats:styled-content style=\"fixed-case\"><jats:italic>Ceratonia siliqua<\/jats:italic><\/jats:styled-content> is known to decrease oxidative stress in urological pathologies. We investigated the protective effects of <jats:styled-content style=\"fixed-case\"><jats:italic>C. siliqua<\/jats:italic><\/jats:styled-content> against I\/R injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Wistar rats (<jats:italic>n<\/jats:italic>\u2009=\u200928) were divided into control, i.p. <jats:italic>C. siliqua<\/jats:italic> injected, I\/R injury group, and <jats:italic>C. siliqua<\/jats:italic> injected each day for a week after I\/R groups. They were morphologically evaluated with light and electron microscopy, and Caspase\u20103, Hypoxia\u2010inducible factor 1 alpha (HIF\u20101), CD68, Superoxide dismutase (SOD), and Catalase antibodies were marked. Oxidative stress markers of Glutathione (GSH), malondialdehyde (MDA), reactive oxygen species (ROS), advanced oxidation protein products (AOPP), and ferric reducing antioxidant power (FRAP) from tissue and levels of testosterone, Anti\u2010M\u00fcllerian hormone (AMH) and inhibin\u2010B from blood samples were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>C.siliqua<\/jats:italic> treatment preserved tissue integrity (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and Leydig cells and decreased apoptotic (<jats:italic>p<\/jats:italic>\u2009=\u20090.0390) and necrotic changes when compared with the I\/R group. The I\/R group presented mitochondrial damage, intercellular edema, and vacuolization. Oxidative stress was less with treatment, but hormone levels were unchanged.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>C.siliqua<\/jats:italic> preserved the testicular tissue against I\/R\u2010induced damage. The decreased apoptosis may have been caused by the significant oxidative stress protection properties of <jats:italic>C<\/jats:italic>.<jats:italic>siliqua<\/jats:italic>. One week of treatment with <jats:italic>C.siliqua<\/jats:italic> protected Leydig cell morphology but did not change hormone parameters in the rat model. The therapeutic effect of <jats:italic>C.siliqua<\/jats:italic> is promising for clinical use in testis torsion cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.70059","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T20:22:06Z","timestamp":1743711726000},"page":"890-899","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<scp><i>Ceratonia siliqua<\/i><\/scp> Protects Testicular Tissue in Ischemia\/Reperfusion Injury"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5483-6896","authenticated-orcid":false,"given":"\u015eahika","family":"Yardim","sequence":"first","affiliation":[{"name":"Istanbul Faculty of Medicine, Department of Histology and Embryology Istanbul University  Istanbul Turkey"},{"name":"Faculty of Medicine, Department of Histology and Embryology Istanbul Medeniyet University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Dursun","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine, Department of Urology, Section of Andrology Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130layda","family":"S\u00f6zmen","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine, Department of Biochemistry Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdurrahman Fatih","family":"Aydin","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine, Department of Biochemistry Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ate\u015f","family":"Kadio\u011flu","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine, Department of Urology, Section of Andrology Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00dcnal","family":"Uslu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Histology and Embryology Istanbul Medeniyet University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif Kervancio\u011flu","family":"Demirci","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine, Department of Histology and Embryology Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2023.01.031"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-061516-045037"},{"key":"e_1_2_10_4_1","first-page":"43","volume-title":"Robbins Temel Patoloji","author":"Kumar V.","year":"2020"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.34172\/apb.2020.023"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2014.135"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/OAEM.S236767"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2016.12.016"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-020-00314-3"},{"issue":"12","key":"e_1_2_10_10_1","first-page":"1029","article-title":"Ceratonia Siliqua L Improved Cryodamage of Asthenozoospermic Specimens: An Experimental Study","volume":"20","author":"Javanmard F.","year":"2022","journal-title":"International Journal of Reproductive BioMedicine"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.15171\/PS.2018.16"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000579"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.13418"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-89369-z"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2007.07406.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.12041"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02439-x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.13351"},{"key":"e_1_2_10_19_1","unstructured":"E.Beutler O.Duron andB. 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