{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T01:27:26Z","timestamp":1768440446241,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To report outcomes of active surveillance (AS) for prostate cancer in men with intermediate\u2010risk features of International Society of Urological Pathology (ISUP) grade group 2 and\/or clinical stage T2 compared with ISUP grade group 1 and clinical stage T1 in the PRIAS\u2010JAPAN study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with prostate cancer diagnosed between January 2010 and February 2024 were included in this study. PSA test, rectal examination, and re\u2010biopsy were performed regularly. We calculated the pathological reclassification rate, program persistence rate, and subsequent treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from 1302 participants were collected. After excluding patients who did not fit inclusion criteria (<jats:italic>n<\/jats:italic>\u2009=\u200928) or follow\u2010up of less than 1\u2009year (<jats:italic>n<\/jats:italic>\u2009=\u2009208), 1066 patients were included in this analysis. The median follow\u2010up was 42.4\u2009months (interquartile range 17.0\u201372.1). There were no statistical differences in the pathological reclassification, persistence rates, and subsequent therapy between low\u2010 and intermediate\u2010risk features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This preliminary study demonstrated medium\u2010term outcomes of AS in prostate cancer with intermediate\u2010risk features in Japan, suggesting no significant difference in the pathological reclassification, persistence rate, and subsequent therapy between low\u2010 and intermediate\u2010risk features.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.70063","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T08:49:05Z","timestamp":1744102145000},"page":"823-827","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Active Surveillance in Prostate Cancer With Intermediate\u2010Risk Features: The <scp>PRIAS<\/scp>\u2010<scp>JAPAN<\/scp> Study"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7383-5322","authenticated-orcid":false,"given":"Leandro","family":"Blas","sequence":"first","affiliation":[{"name":"Department of Urology Graduate School of Medical Sciences, Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3306-4858","authenticated-orcid":false,"given":"Masaki","family":"Shiota","sequence":"additional","affiliation":[{"name":"Department of Urology Graduate School of Medical Sciences, Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuma","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medicine Kagawa University  Takamatsu Kagawa 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