{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:31:15Z","timestamp":1790087475967,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Due to unclear evidence of survival improvement, this study aimed to evaluate the efficacy of neoadjuvant chemotherapy for muscle\u2010invasive bladder cancer in real\u2010world clinical practice in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We initially extracted patients who underwent open radical cystectomy between July 2000 and May 2021 at Kanazawa University Hospital from the medical charts, and we selected patients diagnosed with pure urothelial carcinoma. Progression\u2010free survival and cancer\u2010specific survival were compared based on the presence or absence of neoadjuvant chemotherapy. We also examined prognostic factors related to cancer\u2010specific survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 107 patients who underwent open radical cystectomy, 91 with pure urothelial carcinoma were analyzed. Progression\u2010free survival and cancer\u2010specific survival were significantly different between the presence and absence of neoadjuvant chemotherapy (median progression\u2010free survival: not reached vs. 21.4\u2009months, <jats:italic>p<\/jats:italic>\u2009=\u20090.0167, and median cancer\u2010specific survival: not reached vs. 66.6\u2009months, <jats:italic>p<\/jats:italic>\u2009=\u20090.0017, respectively). Multivariate analysis revealed five independent poor prognostic factors: age\u2009\u2265\u200970\u2009years, pN+, \u2265\u2009pT2, high neutrophil\u2010to\u2010lymphocyte ratio, and high C\u2010reactive protein level. Based on the number of independent poor prognostic factors, the patients were divided into three risk groups that showed significantly different cancer\u2010specific survival (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Neoadjuvant chemotherapy improved the prognosis of patients with muscle\u2010invasive bladder cancer treated with open radical cystectomy in real\u2010world clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.70064","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T10:13:56Z","timestamp":1744366436000},"page":"830-838","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Does Neoadjuvant Chemotherapy Followed by Radical Cystectomy Improve the Survival of Muscle\u2010Invasive Bladder Cancer in Real\u2010World Clinical Practice?"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3936-7235","authenticated-orcid":false,"given":"Renato","family":"Naito","sequence":"first","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science  Kanazawa Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouji","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science  Kanazawa Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuya","family":"Takimoto","sequence":"additional","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science  Kanazawa Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2503-8908","authenticated-orcid":false,"given":"Ryunosuke","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science  Kanazawa Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3543-1236","authenticated-orcid":false,"given":"Hiroshi","family":"Kano","sequence":"additional","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science  Kanazawa Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2554-7048","authenticated-orcid":false,"given":"Tomoyuki","family":"Makino","sequence":"additional","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science  Kanazawa Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3599-2217","authenticated-orcid":false,"given":"Hiroaki","family":"Iwamoto","sequence":"additional","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science  Kanazawa Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3188-8834","authenticated-orcid":false,"given":"Hiroshi","family":"Yaegashi","sequence":"additional","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science  Kanazawa Ishikawa 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