{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:34:08Z","timestamp":1753878848072,"version":"3.41.2"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>We examined whether nocturia could be improved by adhering to an appropriate bedtime as determined using a wearable device that measures sleep\u2013wake activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We enrolled patients aged 65\u2009years or older with nocturia at our institution and associated hospital, for whom medical therapy was either not indicated or ineffective. We conducted a prospective crossover comparative study with alternate 4\u2010week intervention and non\u2010intervention periods with a 2\u2010week washout period. During the intervention, participants were instructed to go to bed at a personalized bedtime determined via the steepest descent method, using the data of bedtime and mid\u2010wake time from an Actiwatch Spectrum (Philips Respironics). A frequency volume chart was administered before and after each period. Sleep quality was evaluated using the Pittsburgh sleep quality index (PSQI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis included 24 patients enrolled for the study. The mean age was 79.7\u2009years. The mean bedtime changed from 21:30 to 22:11 after intervention (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). During the intervention and non\u2010intervention periods, the mean changes were as follows: nocturnal urinary frequency (\u22120.90 vs. \u22120.01 times, <jats:italic>p<\/jats:italic>\u2009&lt; 0.01), nocturnal urine volume (NUV) (\u2212105.6 vs. +4.4\u2009mL, <jats:italic>p<\/jats:italic>\u2009=\u20090.04), hours to undisturbed sleep (HUS) (62.8 vs. 12.7\u2009min, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), NUV per hour during HUS (\u221228.4 vs. \u22120.17\u2009mL\/h, <jats:italic>p<\/jats:italic>\u2009=\u20090.04), and PSQI scores (\u22122.4 vs. 1.2, <jats:italic>p<\/jats:italic>\u2009=\u20090.022).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In older patients with nocturia, going to bed at appropriate times, determined using a wearable device that measures sleep\u2013wake activity, might potentially prolong HUS,\u00a0decrease NUV, specifically NUV\/h during HUS, and consequently improve nocturia and sleep quality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.70068","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T07:43:11Z","timestamp":1745653391000},"page":"870-876","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Adjustment to an Appropriate Bedtime Improves Nocturia in Older Adults: A Crossover Study"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2225-3418","authenticated-orcid":false,"given":"Yoshinaga","family":"Okumura","sequence":"first","affiliation":[{"name":"Department of Urology, Faculty of Medicine University of Fukui  Fukui Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sou","family":"Nobukawa","sequence":"additional","affiliation":[{"name":"Department of Information Engineering Chiba Institute of Technology  Chiba 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