{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T11:02:46Z","timestamp":1771153366818,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To identify clinical predictors of fluoroquinolone\u2010resistant\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Escherichia coli<\/jats:italic>\n                      <\/jats:styled-content>\n                      colonization and evaluate their usefulness in guiding personalized antibiotic prophylaxis for patients undergoing transrectal ultrasound\u2010guided prostate biopsy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective analysis was conducted on 539 patients who underwent biopsy between January 2015 and March 2023 at a high\u2010volume referral center. Clinical data, including demographic, biochemical, and pathological parameters, were extracted. Patients were stratified into high\u2010 and low\u2010risk groups based on the Japanese Urological Association's risk classification. Univariate and multivariate logistic regression analyses were performed to identify independent predictors of fluoroquinolone\u2010resistant\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>E. coli<\/jats:italic>\n                      <\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fluoroquinolone\u2010resistant\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>E. coli<\/jats:italic>\n                      <\/jats:styled-content>\n                      was detected in 17.1% of patients. The prevalence increased significantly over time, from 14.1% in the earlier period (2015\u20132019) to 20.9% in the later period (2019\u20132023) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). Multivariate analysis identified elevated C\u2010reactive protein greater than 0.09\u2009mg\/dL and the use of steroid or immunosuppressive therapy as independent predictors of fluoroquinolone\u2010resistant\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>E. coli<\/jats:italic>\n                      <\/jats:styled-content>\n                      . In high\u2010risk patients, elevated HbA1c greater than 5.9% was also a significant predictor. Notably, patients with fluoroquinolone\u2010resistant flora had significantly lower rates of prostate cancer detection, particularly among low\u2010risk individuals (52.1% vs. 75.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Elevated C\u2010reactive protein and immunosuppressive therapy are strong clinical predictors of fluoroquinolone\u2010resistant\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>E. coli<\/jats:italic>\n                      <\/jats:styled-content>\n                      colonization. These factors should be integrated into pre\u2010biopsy assessment to guide selective rectal swab testing and tailor prophylactic strategies, thereby enhancing patient safety and reducing antibiotic resistance.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70082","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T02:05:00Z","timestamp":1745546700000},"page":"982-989","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Predictors of Fluoroquinolone\u2010Resistant\n                    <i>Escherichia coli<\/i>\n                    in Transrectal Ultrasound\u2010Guided Prostate Biopsy: Insights for Tailored Prophylaxis"],"prefix":"10.1111","volume":"32","author":[{"given":"Takatoshi","family":"Somoto","sequence":"first","affiliation":[{"name":"Department of Urology Toho University Sakura Medical Center  Sakura 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