{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:57:08Z","timestamp":1791284228386,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:00:00Z","timestamp":1746835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:00:00Z","timestamp":1746835200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to evaluate differences in patient characteristics, treatment, and cancer\u2010specific survival between penile cancer patients aged 75\u2009years or older and those younger than 75\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred ninety\u2010six patients with penile cancer who were treated in 12 hospitals in the Kyushu\u2013Okinawa region from 2009 to 2020 were retrospectively analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The older (age\u2009\u2265\u200975\u2009years) and younger (age\u2009&lt;\u200975\u2009years) groups comprised 80 and 116 patients, respectively. Among all patients with clinical stage 3 disease and those with stage 3A alone, cancer\u2010specific survival was significantly worse in the older group. Patients in the older group exhibited worse Eastern Cooperative Oncology Group Performance Status scores, lower albumin concentrations, and higher neutrophil\u2010to\u2010lymphocyte ratios. Treatment intensity was lower in the older patients, but the findings were not significant: partial penile resection was predominant in the older group, while patients in the younger group more frequently underwent total penile resection. In addition, pelvic lymph node dissection was less frequently performed in the older group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among patients with clinical stage 3 penile cancer, cancer\u2010specific survival was worse in those aged 75\u2009years or older. Worse Eastern Cooperative Oncology Group Performance Status scores and less aggressive treatment in the older group may have been contributing factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70090","type":"journal-article","created":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T02:23:07Z","timestamp":1746930187000},"page":"1025-1032","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Penile Cancer: Differences Between Patients Over and Under the Age of 75\u2009Years"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5176-0441","authenticated-orcid":false,"given":"Yoji","family":"Murakami","sequence":"first","affiliation":[{"name":"Department of Urology, Faculty of Life Sciences Kumamoto University  Kumamoto Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0985-7305","authenticated-orcid":false,"given":"Takahiro","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Urology Kumamoto Kenhoku Hospital  Tamana Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Goya","sequence":"additional","affiliation":[{"name":"Department of Urology Chubu Tokushukai Hospital  Kitanakagusuku Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyoshi","family":"Higashijima","sequence":"additional","affiliation":[{"name":"Department of Urology School of Medicine, University of Occupational and Environmental Health  Kitakyushu Fukuoka 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University of Miyazaki  Miyazaki Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei\u2010Ichiro","family":"Uemura","sequence":"additional","affiliation":[{"name":"Department of Urology Kurume University School of Medicine  Kurume Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsunori","family":"Tatsugami","sequence":"additional","affiliation":[{"name":"Department of Urology Kitakyushu Municipal Medical Center  Kitakyushu Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4286-3942","authenticated-orcid":false,"given":"Kazuna","family":"Tsubouchi","sequence":"additional","affiliation":[{"name":"Department of Urology Chihaya Urological Clinic  Fukuoka Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Shida","sequence":"additional","affiliation":[{"name":"Department of Urology Shida Urological Clinic  Nagasaki Nagasaki 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University  Fukuoka Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Eto","sequence":"additional","affiliation":[{"name":"Department of Urology Graduate School of Medical Sciences, Kyushu University  Fukuoka Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsukasa","family":"Igawa","sequence":"additional","affiliation":[{"name":"Department of Urology Kurume University School of Medicine  Kurume Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Kamoto","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medicine University of Miyazaki  Miyazaki Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Enokida","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medicine Kagoshima University  Kagoshima Kagoshima 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