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Poly ADP\u2010ribose polymerase inhibitors (PARPis) have been developed to induce synthetic lethality in tumors with HRD by inhibiting the repair of single\u2010strand DNA breaks. Beyond the initial approach to target cancers associated with HRD, the utility of PARPis has expanded to combination therapy with immune checkpoint inhibitors, anti\u2010angiogenic drugs, or anti\u2010androgen drugs based on the molecular biological rationale. In the field of genitourinary (GU) cancer, PARPis, such as olaparib, rucaparib, and talazoparib, are approved by the Food and Drug Administration in metastatic prostate cancer patients with\n                    <jats:italic>BRCA1<\/jats:italic>\n                    \/\n                    <jats:italic>2<\/jats:italic>\n                    mutations, sometimes in combination with other agents (e.g., olaparib plus abiraterone acetate, or talazoparib plus enzalutamide). More recently, pivotal clinical trials have broadened the potential of PARPis to the other GU cancers, including urothelial carcinoma and renal cell carcinoma. In this review, we examine the biomarkers for the response to PARPis beyond mutations in\n                    <jats:italic>BRCA1<\/jats:italic>\n                    \/\n                    <jats:italic>2<\/jats:italic>\n                    and discuss the current state and future perspectives of PARPis in GU cancers.\n                  <\/jats:p>","DOI":"10.1111\/iju.70100","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T10:49:16Z","timestamp":1749466156000},"page":"1091-1101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>PARP<\/scp>\n                    Inhibitors in Genitourinary Cancer: A New Paradigm Beyond Prostate Cancer"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9909-4200","authenticated-orcid":false,"given":"Yohei","family":"Okuda","sequence":"first","affiliation":[{"name":"Department of Urology Osaka University Graduate 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