{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T07:16:35Z","timestamp":1773818195549,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Patients with an intermediate risk prostate cancer (PCa) are not routinely offered nerve sparing (NS). Implementation of whole surface frozen section (FS) made NS\u2010radical prostatectomy (RP) available and oncologically safe. In the present study, we aimed to assess the impact of the addition of FS on NS during RP and potentially improved functional outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Institutional data of patients (PSA \u2264\u200920\u2009ng\/mL, Gleason\u2010Score \u2264\u20097, cT1c\u2010cT2c) undergoing RP between 06\/2011 and 11\/2014 were prospectively collected. Decision for NS was made by the surgeon supported by FS. Only patients with a preoperative International Index of Erectile Function (IIEF\u20105) \u2265\u200917 were analyzed for potency. Continence was defined as pad use of \u2264\u20091 pad\/day. Separate multivariable regression analyses were employed to examine predictors for both endpoints (i.e., potency and continence).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 702 patients were included in this study. Final nerve\u2010sparing surgery was performed in 671 patients (95.6%). Before the introduction of FS, only 392 patients (56%) would have undergone NS\u2010RP. FS enabled intraoperative\/final NS for 688 (98%) and 666 (95%) patients. No differences at overall follow\u2010up between low\u2010 and intermediate\u2010risk patients regarding continence (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009122 (84.1%) vs.\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009223 (82.6%),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.689) and potency (IIEF\u20105\u2009\u2265\u200917,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200916\/47 vs. 26\/68,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.646) were detected. Surgeon volume was associated with improved continence (OR 3.69, 95% CI 1.86\u20137.32,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and erectile function (EF) (OR 2.49, 95% CI 1.23\u20135.03,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The introduction of FS expanded NS to patients with an intermediate\u2010risk PCa and selected high\u2010risk PCa. This may lead to improved functional outcomes as more patients were eligible for NS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70115","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T07:26:15Z","timestamp":1747725975000},"page":"1159-1164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Functional Outcomes in Patients With Prostate Cancer Undergoing Frozen Section Guided Radical Prostatectomy"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1161-4196","authenticated-orcid":false,"given":"Moritz J.","family":"Reike","sequence":"first","affiliation":[{"name":"Department of Urology Marien Hospital Herne, Ruhr\u2010University Bochum  Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9499-0169","authenticated-orcid":false,"given":"Karl H.","family":"Tully","sequence":"additional","affiliation":[{"name":"Department of Urology Marien Hospital Herne, Ruhr\u2010University Bochum  Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian","family":"Schulmeier","sequence":"additional","affiliation":[{"name":"Department of Urology Marien Hospital Herne, Ruhr\u2010University Bochum  Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina","family":"Reicherz","sequence":"additional","affiliation":[{"name":"Department of Urology Marien Hospital Herne, Ruhr\u2010University Bochum  Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Bahlburg","sequence":"additional","affiliation":[{"name":"Department of Urology Marien Hospital Herne, Ruhr\u2010University Bochum  Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Urology Marien Hospital Herne, Ruhr\u2010University Bochum  Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0284-4624","authenticated-orcid":false,"given":"Peter","family":"Bach","sequence":"additional","affiliation":[{"name":"Department of Urology Marien Hospital Herne, Ruhr\u2010University Bochum  Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Sternemann","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Ruhr\u2010University Bochum  Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Tannapfel","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Ruhr\u2010University Bochum  Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Noldus","sequence":"additional","affiliation":[{"name":"Department of Urology Marien Hospital Herne, Ruhr\u2010University Bochum  Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Brock","sequence":"additional","affiliation":[{"name":"Department of Urology Marien Hospital Herne, Ruhr\u2010University Bochum  Bochum Germany"},{"name":"Department of Urology Stiftungsklinikum PROSELIS  Recklinghausen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Roghmann","sequence":"additional","affiliation":[{"name":"Department of Urology Marien Hospital Herne, Ruhr\u2010University Bochum  Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.01.026"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-014-1340-3"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.07.037"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000002758"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.15446"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.04.057"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.02.011"},{"issue":"6","key":"e_1_2_10_9_1","first-page":"S11","article-title":"Identifying Men Diagnosed With Clinically Localized Prostate Cancer Who Are at High Risk for Death From Prostate Cancer","volume":"176","author":"D'Amico A. 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