{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:40:15Z","timestamp":1777668015504,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The optimal timing of radical prostatectomy (RP) after prostate cancer diagnosis is controversial, particularly concerning the impact of surgical delays on oncological outcomes. While active surveillance is standard for low\u2010risk prostate cancer, the effects of delaying surgery in intermediate\u2010 and high\u2010risk patients are less clear. We aimed to evaluate the impact of surgical delays exceeding 9\u2009months on pathological outcomes: upstaging (pT\u2009\u2265\u20093a), upgrading (ISUP\u2009\u2265\u20094) and biochemical recurrence (BCR) in patients undergoing RP with a localized disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective cohort study was conducted across four French academic hospitals between June 2013 and June 2021, including consecutive patients scheduled for RP according to established clinical guidelines. A 9\u2010month surgical delay threshold between prostate biopsies and surgery was chosen. The primary endpoint was BCR rates while secondary endpoints included International Society of Urological Pathology (\u2265\u2009ISUP 4) upgrading and\u2009\u2265\u2009pT3a upstaging. A propensity score was used to homogenize PSA levels, biopsy ISUP, and D'Amico risk categories between both populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After propensity score matching, 881 patients were analyzed, with a median surgical delay of 3.5\u2009months IQR (2.6\u20134.6). After a median follow\u2010up of 48.0\u2009months IQR (25.0\u201360.0), BCR occurred in 156 patients (17.7%). Delaying surgery of more than 9\u2009months was not significantly associated with worse BCR\u2010free survival in patients with PSA &lt;\u200920\u2009ng\/mL and ISUP grade &lt;\u20094 (D'Amico low to intermediate high). Upgrading (ISUP \u2265\u20094) and\/or upstaging (\u2265\u2009pT3a) occurred in 35% of patients, but was not impacted by a surgical delay of more than 9\u2009months in the multivariate model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Delaying surgery over 9\u2009months does not seem to adversely impact pathological outcomes and BCR rates in nonhigh\u2010risk patients undergoing RP for localized prostate cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>NCT02235142<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70142","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T03:03:02Z","timestamp":1749006182000},"page":"1243-1249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluating the Safety of Delaying Surgery Beyond 9\u2009Months in Localized Prostate Cancer Patients: Results From a Prospective Study With Propensity Score Matching"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5946-1771","authenticated-orcid":false,"given":"Maxime","family":"Pattou","sequence":"first","affiliation":[{"name":"Department of Urology University of Versailles\u2010Saint\u2010Quentin\u2010En\u2010Yvelines, Foch Hospital  Suresnes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yann","family":"Neuzillet","sequence":"additional","affiliation":[{"name":"Department of Urology University of Versailles\u2010Saint\u2010Quentin\u2010En\u2010Yvelines, Foch Hospital  Suresnes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek","family":"Ghoneim","sequence":"additional","affiliation":[{"name":"Department of Urology University of Versailles\u2010Saint\u2010Quentin\u2010En\u2010Yvelines, Foch Hospital  Suresnes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre\u2010Olivier","family":"Bosset","sequence":"additional","affiliation":[{"name":"Department of Urology University of Versailles\u2010Saint\u2010Quentin\u2010En\u2010Yvelines, Foch Hospital  Suresnes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Vanalderverelt","sequence":"additional","affiliation":[{"name":"Department of Urology University of Versailles\u2010Saint\u2010Quentin\u2010En\u2010Yvelines, Foch Hospital  Suresnes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Bohin","sequence":"additional","affiliation":[{"name":"Department of Urology University of Versailles\u2010Saint\u2010Quentin\u2010En\u2010Yvelines, Foch Hospital  Suresnes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre\u2010Marie","family":"Lugagne","sequence":"additional","affiliation":[{"name":"Department of Urology University of Versailles\u2010Saint\u2010Quentin\u2010En\u2010Yvelines, Foch Hospital  Suresnes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanish","family":"Soorojebally","sequence":"additional","affiliation":[{"name":"Department of Urology University of Versailles\u2010Saint\u2010Quentin\u2010En\u2010Yvelines, Foch Hospital  Suresnes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Urology Louis Pasteur Hospital  Colmar France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Cathelineau","sequence":"additional","affiliation":[{"name":"Department of Urology Institut Mutualiste Montsouris, Paris\u2010Descartes University  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morgan","family":"Roupr\u00eat","sequence":"additional","affiliation":[{"name":"Sorbonne University GRC 5 Predictive Onco\u2010Uro, AP\u2010HP, Urology, Pitie\u2010Salpetriere Hospital  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah J.","family":"Drouin","sequence":"additional","affiliation":[{"name":"Department of Urology Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Assistance Publique  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Lebret","sequence":"additional","affiliation":[{"name":"Department of Urology University of Versailles\u2010Saint\u2010Quentin\u2010En\u2010Yvelines, Foch Hospital  Suresnes France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.55.1192"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606220"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345\u2010021\u201003703\u20108"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345\u2010020\u201003402\u2010w"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.22582"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1677\u20105538.ibju.2018.0196"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14659"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/2051415820945933"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464\u2010410X.2007.07410.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000820"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.01.050"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.08.003"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102020\u2010044420"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djp122"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26169"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000001089"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14671"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2024.108398"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345\u2010018\u20102251\u20105"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345\u2010018\u20102570\u20106"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2014.12.012"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2016.11.010"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910038"},{"key":"e_1_2_9_25_1","doi-asserted-by":"crossref","unstructured":"R.\u2010B.Incesu F.Preisser F.Nohe T.Maurer M.Graefen andD.Tilki \u201cNegative PSMA PET Can Be Used to Avoid Unnecessary Pelvic Lymph Node Dissection in Intermediate Risk Prostate Cancer \u201dProstate Cancer and Prostatic Diseases ahead of print January 6 2025 https:\/\/doi.org\/10.1038\/s41391\u2010024\u201000930\u2010z.","DOI":"10.1038\/s41391-024-00930-z"}],"container-title":["International Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.70142","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iju.70142","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.70142","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T06:14:25Z","timestamp":1773814465000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iju.70142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,4]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/iju.70142"],"URL":"https:\/\/doi.org\/10.1111\/iju.70142","archive":["Portico"],"relation":{},"ISSN":["0919-8172","1442-2042"],"issn-type":[{"value":"0919-8172","type":"print"},{"value":"1442-2042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,4]]},"assertion":[{"value":"2025-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}