{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:00:10Z","timestamp":1793829610744,"version":"4.6.1"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The phase 3 ARASENS and PEACE\u20101 studies demonstrated significant survival benefits from triplet therapy (androgen deprivation therapy [ADT] plus androgen receptor signaling inhibitor plus docetaxel) versus ADT plus docetaxel alone. We examined the efficacy and safety of triplet therapy using the prospective observational clinical study: YUSHIMA study database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed data on patients with metastatic hormone\u2010sensitive prostate cancer (mHSPC) treated with triplet therapy extracted from the YUSHIMA study database. Deep and early prostate\u2010specific antigen (PSA) response was defined as \u2265\u200990% PSA decline or PSA \u2264\u20090.2\u2009ng\/mL achievable at 3\u2009months of treatment. Kaplan\u2013Meier curves were used to assess overall survival (OS) and castration\u2010resistant prostate cancer (CRPC)\u2013free survival. Adverse events (AEs) were graded using Common Terminology Criteria for Adverse Events version 5.0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 317 patients were enrolled in the YUSHIMA study from 2021 to 2025, of which 48 received triplet therapy. Organ metastases accounted for 25%. According to the CHAARTED and LATITUDE criteria, 77% and 73% of patients exhibited high\u2010volume and high\u2010risk disease, respectively. The 1\u2010year OS and CRPC\u2010free survival rates were 88% and 79%, respectively. Deep and early PSA response was achieved in 98%. In our cohort, grade 3\u20134 AEs appeared in 89% of cases, most of which were neutropenia. In 20% of cases, 6 courses of docetaxel could not be completed due to AEs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Triplet therapy was highly efficacious and tolerable in Japanese mHSPC patients. Although most patients experienced grade 3\u20134 neutropenia, no cases were fatal. The deep and early PSA response represents a satisfactory short\u2010term result.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70154","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T02:44:02Z","timestamp":1750128242000},"page":"1413-1418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Preliminary Report on the Efficacy and Safety of Triplet Therapy in Patients With Metastatic Hormone\u2010Sensitive Prostate Cancer:\n                    <scp>YUSHIMA<\/scp>\n                    Study"],"prefix":"10.1111","volume":"32","author":[{"given":"Yosuke","family":"Yasuda","sequence":"first","affiliation":[{"name":"Department of Urology Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Numao","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Oncology Cancer Institute 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