{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:49:10Z","timestamp":1778543350816,"version":"3.51.4"},"reference-count":61,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,6,22]],"date-time":"2025-06-22T00:00:00Z","timestamp":1750550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,22]],"date-time":"2025-06-22T00:00:00Z","timestamp":1750550400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21K09357"],"award-info":[{"award-number":["JP21K09357"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Focal therapy is a minimally invasive alternative treatment for localized prostate cancer (PC) aiming to achieve oncological control while preserving urinary and sexual functions. High\u2010intensity focused ultrasound (HIFU) and high\u2010intensity directional ultrasound (HIDU) enable precise prostate ablation guided by real\u2010time transrectal ultrasound or magnetic resonance imaging (MRI) fusion imaging. This review evaluates the current status and prospects of ultrasound technology in the treatment of PC. HIFU provides precise tumor ablation with minimal damage to the surrounding tissues, whereas HIDU allows MRI\u2010guided transurethral treatment with real\u2010time thermometry. Clinical studies have reported favorable biochemical recurrence\u2010free survival and functional outcomes. In Japan, a multi\u2010institutional prospective study on focal therapy using HIFU has been approved as an advanced medical technology by the Minister of Health, Labor, and Welfare. This study compared the oncological and functional outcomes of HIFU\u2010based focal therapy and radical prostatectomy in pair\u2010matched patients to evaluate the effectiveness of HIFU in treating localized PC. HIFU induces immunogenic cell death, releases tumor\u2010associated antigens, and reduces immunosuppressive cells. Low\u2010intensity focused ultrasound enhances tumor immunogenicity by promoting heat shock protein expression and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell activation. In conclusion, HIFU and HIDU offer effective focal therapy options for localized PC, and the immunomodulatory properties of HIFU and low\u2010intensity focused ultrasound may benefit advanced PC treatment. Future studies should optimize patient selection by developing advanced imaging technologies and predictive models capable of visualizing MRI\u2010invisible lesions and accurately detecting micro\u2010metastatic disease. Moreover, evaluating long\u2010term outcomes and exploring their combination with immunotherapy to enhance oncological efficacy will be essential.\n                  <\/jats:p>","DOI":"10.1111\/iju.70160","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T02:23:30Z","timestamp":1750645410000},"page":"1321-1332","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Frontiers of Ultrasound Technology in Prostate Cancer Treatment"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6673-9316","authenticated-orcid":false,"given":"Sunao","family":"Shoji","sequence":"first","affiliation":[{"name":"Department of Urology Tokai University School of Medicine  Isehara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumpei","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Urology Tokai University School of Medicine  Isehara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Naruse","sequence":"additional","affiliation":[{"name":"Department of Urology Tokai University School of Medicine  Isehara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Department of Urology Tokai University School of Medicine  Isehara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,22]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.2806"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000002757"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11701-021-01242-3"},{"key":"e_1_2_16_5_1","first-page":"543","article-title":"Management of Erectile Dysfunction Following Robot\u2010Assisted Radical Prostatectomy: A Systematic Review","volume":"72","author":"Marchioni M.","year":"2020","journal-title":"Minerva Urologica e Nefrologica"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-015-0443-5"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/pcan.2015.4"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10396\u2010021\u201001183\u20102"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000001362"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.04.039"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2021.1945150"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-018-5409-z"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(22)00251-0"},{"key":"e_1_2_16_14_1","first-page":"3346","article-title":"Effect of High\u2010Intensity Focused Ultrasound on Human Prostate Cancer In\u00a0Vivo","volume":"55","author":"Madersbacher S.","year":"1995","journal-title":"Cancer Research"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.122.3168.517"},{"key":"e_1_2_16_16_1","first-page":"6353","article-title":"In Vivo Effects of High\u2010Intensity Ultrasound on Prostatic Adenocarcinoma Dunning R3327","volume":"52","author":"Chapelon J. 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