{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:52:15Z","timestamp":1776905535588,"version":"3.51.2"},"reference-count":62,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Tissue engineering, a key component of regenerative medicine, aims to restore the structure and function of damaged organs using combinations of cells, scaffolds, and bioactive factors. In urology, the integration of stem cell biology has fueled significant progress in preclinical models for kidney, bladder, and urethral regeneration. Pluripotent stem cells, such as embryonic stem cells and induced pluripotent stem cells, offer broad differentiation potential, particularly in kidney organoid development. Meanwhile, multipotent stem cells\u2014especially mesenchymal stem cells and urine\u2010derived stem cells\u2014have shown promise in bladder and urethral repair due to their immunomodulatory properties and relative ease of use. Despite these advancements, certain challenges remain: vascularization, functional integration, long\u2010term safety, and scalability continue to limit the clinical application of regenerated organs. In kidney regeneration, issues such as nephron\u2010collecting duct connectivity and urinary outflow remain unresolved. For the bladder and urethra, the need for vascularized, contractile, and innervated tissue complicates scaffold and cell selection. Nonetheless, clinical translation is becoming increasingly realistic. As the field evolves rapidly, it is essential for urologists to remain informed and actively engage in collaborative research. By integrating clinical expertise with basic science, urologists can play a crucial role in guiding regenerative strategies toward effective, patient\u2010specific therapies.<\/jats:p>","DOI":"10.1111\/iju.70196","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T09:20:41Z","timestamp":1754558441000},"page":"1535-1543","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Current Progress of Tissue Engineering With Stem Cells in Urology Updated Review in 2025"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6618-5664","authenticated-orcid":false,"given":"Kenichi","family":"Kobayashi","sequence":"first","affiliation":[{"name":"The Department of Urology Shiga University of Medical Science  Otsu Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsunehito","family":"Horii","sequence":"additional","affiliation":[{"name":"The Department of Urology Shiga University of Medical Science  Otsu Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7924-9519","authenticated-orcid":false,"given":"Akinori","family":"Wada","sequence":"additional","affiliation":[{"name":"The Department of Urology Shiga University of Medical Science  Otsu Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"The Department of Urology Shiga University of Medical Science  Otsu Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akeo","family":"Hagiwara","sequence":"additional","affiliation":[{"name":"The Department of Urology Shiga University of Medical Science  Otsu Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7150-647X","authenticated-orcid":false,"given":"Susumu","family":"Kageyama","sequence":"additional","affiliation":[{"name":"The Department of Urology Shiga University of Medical Science  Otsu Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.620962"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68438-9"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8493529"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1069210"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2015.06.007"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.21666"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2009.0562"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2011.06.008"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.720"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1608368"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering9110605"},{"key":"e_1_2_13_13_1","article-title":"The Impact and Implications of Regenerative Medicine in Urology","volume":"16","author":"Abuharb A. 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