{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T20:37:18Z","timestamp":1783370238743,"version":"3.54.6"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,16]],"date-time":"2025-08-16T00:00:00Z","timestamp":1755302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,16]],"date-time":"2025-08-16T00:00:00Z","timestamp":1755302400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Visceral fat accumulation is significantly associated with urinary stone disease. Meanwhile, abnormalities in urine composition that may cause stone formation can be identified by 24\u2010h urine chemistries. We investigate the effect of visceral fat area (VFA) on 24\u2010h urine chemistries and stone recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed the records of consecutive patients with upper urinary stones that underwent 24\u2010h urine chemistries at our hospital. We analyzed two cohorts according to exclusion criteria: Cohort 1 included 194 patients and Cohort 2 included 164 patients after exclusion of 30 patients with short follow\u2010up. Body composition parameters, including VFA, were automatically measured from noncontrast\u2010computed tomography. In Cohort 1, we performed logistic regression analyses to identify predictors associated with the past stone history and compared 24\u2010h urine chemistries parameters according to VFA. In Cohort 2, the log\u2010rank test was performed to examine factors associated with stone recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In Cohort 1, 67% of the patients had a past stone history. Larger VFA and higher VFAR were significant independent factors associated with past stone history (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04 and 0.03). Additionally, urine volume (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) and urinary excretion of creatinine, uric acid, sodium, phosphate (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), and oxalate (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) were significantly higher in the patients with VFA\u2009\u2265\u2009100\u2009cm\n                      <jats:sup>2<\/jats:sup>\n                      . In Cohort 2, 48% had stone recurrence, and the median follow\u2010up period from 24\u2010h urine chemistries was 42\u2009months (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u200928\u201380\u2009months). Only VFA was significantly associated with stone recurrence (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Larger VFA resulted in abnormal urine chemistries that promote urinary stone formation, leading to the increased risk of stone recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70203","type":"journal-article","created":{"date-parts":[[2025,8,16]],"date-time":"2025-08-16T07:14:33Z","timestamp":1755328473000},"page":"1660-1667","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Impact of Visceral Fat Accumulation on 24\u2010h Urine Chemistries and Stone\u2010Recurrence in Patients With Urolithiasis"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9573-8371","authenticated-orcid":false,"given":"Ryusuke","family":"Deguchi","sequence":"first","affiliation":[{"name":"Department of Urology Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6103-6320","authenticated-orcid":false,"given":"Yasuo","family":"Kohjimoto","sequence":"additional","affiliation":[{"name":"Department of Urology Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Urology Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Mashima","sequence":"additional","affiliation":[{"name":"Department of Urology Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Iwahashi","sequence":"additional","affiliation":[{"name":"Department of Urology Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Kawabata","sequence":"additional","affiliation":[{"name":"Department of Urology Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Muraoka","sequence":"additional","affiliation":[{"name":"Department of Urology Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahito","family":"Wakamiya","sequence":"additional","affiliation":[{"name":"Department of Urology Wakayama Medical University  Wakayama 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