{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T05:30:37Z","timestamp":1773639037511,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The efficacy of local therapy for oligometastatic prostate cancer has been increasingly reported; however, there is little evidence regarding the treatment of patients with castration\u2010resistant disease compared with that for those with castration\u2010sensitive disease. In this retrospective study, we examined data of patients with oligoprogressive castration\u2010resistant prostate cancer (CRPC) treated with progressive site\u2010directed therapy (PSDT) and investigated the prognosticators of treatment efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The cohort comprised 35 patients with oligoprogressive CRPC who underwent radiotherapy in the form of PSDT. Oligoprogression was defined as the presence of five or fewer affected sites. Radiation was administered to all lesions without interruption or modification of systemic therapy. The endpoints were prostate\u2010specific antigen (PSA) response, progression\u2010free survival (PFS), and cancer\u2010specific survival (CSS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The most common site was bone (57.1%), and the prostate was a site in 10 (28.6%) patients. Twenty patients (57.1%) achieved a PSA response of \u2265\u200950%. The median PFS and CSS were 8.0\u2009months (95% confidence interval [CI], 2.3\u201322.8) and 28.7\u2009months (95% CI, 17.6\u2013not reached), respectively. Multivariate analysis identified time to oligoprogression from the initiation of the most recent systemic treatment \u2265\u20091\u2009year as a favorable prognostic factor of PFS (hazard ratio [HR], 0.35; 95% CI, 0.13\u20130.94;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038). One patient (2.9%) developed urinary frequency (Grade 2).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PSDT for oligoprogressive CRPC may achieve good disease control in patients who evidenced time to oligoprogression \u2265\u20091\u2009year after the initiation of the most recent systemic treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70217","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T06:08:56Z","timestamp":1756879736000},"page":"1784-1791","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Time to Oligoprogression From the Initiation of the Most Recent Systemic Treatment Is Associated With the Outcome of Progressive Site\u2010Directed Therapy for Castration\u2010Resistant Prostate Cancer"],"prefix":"10.1111","volume":"32","author":[{"given":"Naoki","family":"Matsuyama","sequence":"first","affiliation":[{"name":"Division of Urology Kobe University Graduate School of Medicine  Kobe Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4589-9251","authenticated-orcid":false,"given":"Kotaro","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of Urology Kobe University Graduate School of Medicine  Kobe Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9289-9014","authenticated-orcid":false,"given":"Taisuke","family":"Tobe","sequence":"additional","affiliation":[{"name":"Division of Urology Kobe University Graduate School of Medicine  Kobe Hyogo 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