{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:14:21Z","timestamp":1785428061268,"version":"3.56.0"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Photodynamic diagnosis\u2010assisted transurethral resection of bladder tumors with oral 5\u2010aminolevulinic acid administration improves tumor visibility but results in perioperative hypotension. In 2024, the recommended timing of 5\u2010aminolevulinic acid administration was revised to enable oral intake 2\u20138\u2009h preoperatively, thereby making it easier to adjust the timing of drug administration and surgery. This study aimed to investigate the association between the interval from 5\u2010aminolevulinic acid administration to the start of surgery and perioperative blood pressure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 112 consecutive patients who underwent photodynamic diagnosis\u2010assisted transurethral resection of bladder tumors from July 2022 to June 2024. Patients were categorized based on the time between oral 5\u2010aminolevulinic acid administration and spinal or general anesthesia induction into the control (&lt;\u20094\u2009h) and extended time (\u2265\u20094\u2009h) groups. The perioperative blood pressure and severity of hypotension were compared between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The extended time group comprised fewer cases of moderate to severe hypotension than the control group (38% and 61%, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039). Blood pressure was significantly higher at several time points intraoperatively in the extended time group. Further, the extended time group required fewer doses of vasopressor agents (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>An interval of more than 4\u2009h from oral 5\u2010aminolevulinic acid intake to anesthesia administration may reduce the risk of perioperative hypotension during photodynamic diagnosis\u2010assisted transurethral resection of bladder tumors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70226","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T07:36:11Z","timestamp":1759131371000},"page":"1827-1833","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association Between Preoperative 5\u2010Aminolevulinic Acid Administration Timing and Perioperative Hypotension"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0355-1005","authenticated-orcid":false,"given":"Tomohiro","family":"Hori","sequence":"first","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science  Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9792-2068","authenticated-orcid":false,"given":"Takahiro","family":"Nohara","sequence":"additional","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science  Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Kawahara","sequence":"additional","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science  Kanazawa 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