{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:37:00Z","timestamp":1781311020950,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T00:00:00Z","timestamp":1757808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T00:00:00Z","timestamp":1757808000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To report the long\u2010term clinical outcomes of transurethral resection of Hunner lesions with bladder hydrodistension in patients with Hunner lesion interstitial cystitis (HIC) at a tertiary referral center in Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective chart review was conducted to evaluate the treatment outcomes of 104 patients with HIC who underwent initial endoscopic surgery, including transurethral resection of Hunner lesions (ablation was kept to a minimum) and concomitant bladder hydrodistension between 2017 and 2023. Clinical outcomes were evaluated and compared between each follow\u2010up visit and baseline over 12\u2009months using a 7\u2010graded global response assessment (GRA), O'Leary and Sant's symptom and problem indices (OSSI\/OSPI), an 11\u2010point pain intensity numerical rating scale, quality of life (QOL) score, and frequency volume chart variables. Patients with GRA scores \u2265\u2009+2 (moderately\/marked improved) and scores \u2264\u2009\u22121 (slightly\/moderately\/marked worse) were considered treatment responders and failures, respectively. Postoperative complications were also documented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean duration to treatment failure was 30.9\u2009\u00b1\u200921.0\u2009months. The overall response rates at 1, 3, 6, 9, and 12\u2009months were 78.8%, 80.8%, 76.0%, 69.2%, and 57.7%, respectively. Compared with the baseline, the OSSI\/OSPI, pain intensity, QOL score, urinary frequency, and functional bladder capacity improved significantly after 1\u2009month and were maintained over 12\u2009months. One patient required a second surgery for postoperative bleeding and another developed distal urethral stenosis 6\u2009months post\u2010surgery. No other patients developed any postoperative complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Transurethral resection of Hunner lesions combined with bladder hydrodistension offers long\u2010term symptom relief without serious adverse events for treatment\u2010na\u00efve patients with HIC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70227","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T06:27:28Z","timestamp":1757917648000},"page":"1834-1842","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Long\u2010Term Clinical Outcomes of Transurethral Resection of Hunner Lesions Combined With Bladder Hydrodistension for Patients With Interstitial Cystitis at a Tertiary Referral Center in Japan"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1439-5640","authenticated-orcid":false,"given":"Yoshiyuki","family":"Akiyama","sequence":"first","affiliation":[{"name":"Department of Urology Shinshu University School of Medicine  Nagano Japan"},{"name":"Department of Urology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Niimi","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Homma","sequence":"additional","affiliation":[{"name":"Department of Interstitial Cystitis Medicine Kyorin University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruki","family":"Kume","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine The University of Tokyo  Tokyo 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