{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T01:28:59Z","timestamp":1769563739567,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The glucocorticoid receptor beta (GR\u03b2) not only inhibits the function of the glucocorticoid receptor but also possesses unique transcriptional activity. Whereas the role of GR\u03b2 varies among different cancer types, its significance in bladder cancer remains unclear. This study aimed to investigate the clinical significance of GR\u03b2 expression in bladder cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Immunohistochemical analysis was performed on tissue samples obtained from 106 patients who underwent surgery for bladder cancer. The immunoreactivity of GR\u03b2 was evaluated using the labeling index (0%\u2013100%). The association between GR\u03b2 expression and clinical parameters obtained from medical records was analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      GR\u03b2 expression was significantly lower in muscle\u2010invasive bladder cancer (\u2265\u2009pT2) compared with non\u2010muscle\u2010invasive cases (\u2264\u2009pT1) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0177). Furthermore, patients who experienced intravesical recurrence after surgery exhibited significantly lower GR\u03b2 expression (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0179).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that GR\u03b2 may serve as a potential biomarker for predicting the progression and recurrence of bladder cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70254","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:30:34Z","timestamp":1760556634000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Expression of Glucocorticoid Receptor Beta in Bladder Cancer and Its Clinicopathological Significance: A Novel Diagnostic Marker to Predict Progression and Recurrence of Cancer"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2256-7898","authenticated-orcid":false,"given":"Takashi","family":"Kukimoto","sequence":"first","affiliation":[{"name":"Division of Urology, Faculty of Medicine Tohoku Medical and Pharmaceutical University  Sendai Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Division of Pathology, Faculty of Medicine Tohoku Medical and Pharmaceutical University  Sendai Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuko","family":"Hata","sequence":"additional","affiliation":[{"name":"Division of Pathology, Faculty of Medicine Tohoku Medical and Pharmaceutical University  Sendai Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Shimada","sequence":"additional","affiliation":[{"name":"Division of 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