{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:51:31Z","timestamp":1793224291843,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Male infertility is influenced by a variety of etiologies, including quantitative and qualitative impairments in spermatogenesis. Antioxidants scavenge reactive oxygen species (ROS), which reduce sperm motility, cause damage to DNA, and lead to subsequent apoptosis in sperm cells. This trial aimed to evaluate the effect of oral Synbiotic and a multivitamin\u2010mineral supplement for men helping to improve male fertility (SperiGen), as an antioxidant agent, on the spermatogram in idiopathic Oligoasthenoteratozoospermia (iOAT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This double\u2010blind randomized clinical trial was conducted on infertile males with iOAT. Totally, 73 patients with iOAT were blindly randomized into two groups; one group received SperiGen as an antioxidant agent in addition to placebo. In the next group, in addition to SperiGen, the patients received 500\u2009mg Synbiotic (FamiLact) on a daily basis. They continued their treatments for 3\u2009months. Semen parameters were measured before and after the intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Supplementations with a combination of Synbiotic and SperiGen compared with SperiGen and placebo significantly increased the average change of sperm progressive motility (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), DNA fragmentation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), and diminished the levels of non\u2010motile sperm (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018). Eventually, within\u2010group analysis indicated that all parameters were significantly improved in both groups, except for non\u2010progressive motility in the SperiGen and placebo group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The combination of Synbiotic and SperiGen (an antioxidant supplement) appears to be much more effective than using an antioxidant alone in improving the DNA fragmentation, concentration, and progressive motility of sperm.<\/jats:p>\n                    <jats:p>\n                      Trial Registration: IRCT20190810044500N6, 2020\u201009\u201005.\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/irct.behdasht.gov.ir\/trial\/46773\">https:\/\/irct.behdasht.gov.ir\/trial\/46773<\/jats:ext-link>\n                      .\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/trial.medpath.com\/clinical-trial\/7ad7a7af5cba37f3\/evaluating-symbiotic-therapy-male-infertility?utm_source=chatgpt.com\">https:\/\/trial.medpath.com\/clinical\u2010trial\/7ad7a7af5cba37f3\/evaluating\u2010symbiotic\u2010therapy\u2010male\u2010infertility<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70255","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T02:35:39Z","timestamp":1765593339000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Investigating the Effect of Synbiotic and\n                    <scp>SperiGen<\/scp>\n                    Supplementations on Spermatogram in Idiopathic Oligoasthenoteratozoospermia: A Double\u2010Blinded Randomized Clinical Trial"],"prefix":"10.1111","volume":"33","author":[{"given":"Ali","family":"Zarehoroki","sequence":"first","affiliation":[{"name":"Department of Urology, Faculty of Medicine Shahid Sadoughi University of Medical Sciences  Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serajodin","family":"Vahidi","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medicine Shahid Sadoughi University of Medical Sciences  Yazd Iran"},{"name":"Andrology Research Center Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences  Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeleh","family":"Sahebnasagh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Clinical Research Center Faculty of Medicine, North Khorasan University of Medical Sciences  Bojnurd 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