{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T03:13:03Z","timestamp":1769569983548,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to assess the association between post\u2010biopsy complications and approach routes in MRI\u2013ultrasound fusion biopsy (FB) using propensity score\u2010matched analysis to adjust for patient background characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 778 FB\u2010na\u00efve patients who underwent FB for suspected prostate cancer between June 2017 and November 2022. Patients were consecutively assigned to transrectal FB (TR\u2010FB) and transperineal FB (TP\u2010FB) groups. Propensity score matching was performed to adjust for age, prostate volume, number of targeted lesions, diabetes, pre\u2010existing pyuria, and the use of antithrombotic drugs between the groups. Post\u2010biopsy complications, including hematuria, acute prostatitis, urinary retention, and rectal bleeding, were graded according to the Common Terminology Criteria for Adverse Events version 5.0, and the incidence rates were compared. Multivariable analysis was performed to explore the risk factors for grade \u2265\u20092 acute prostatitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 427 and 351 patients underwent TR\u2010FB and TP\u2010FB, respectively. In the matched cohort, grade \u2265\u20092 acute prostatitis occurred significantly more frequently in the TR\u2010FB group than in the TP\u2010FB group (3.4% vs. 0.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006). A similar difference was observed in grade 3 acute prostatitis (2.2% vs. 0.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015). No significant differences were observed in any other complications. Multivariable analysis identified the TR approach (odds ratio [OR] 12.11,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018) and use of antithrombotic drugs (OR 5.07,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018) as independent risk factors for grade \u2265\u20092 acute prostatitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TP\u2010FB was associated with a significantly lower risk of acute prostatitis than TR\u2010FB, suggesting that the transperineal approach should be considered from a safety perspective.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70275","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T10:25:56Z","timestamp":1762165556000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Approach Routes in\n                    <scp>MRI<\/scp>\n                    \u2013Ultrasound Fusion Prostate Biopsy on Post\u2010Biopsy Complications: A Propensity Score\u2010Matched Analysis"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3003-3833","authenticated-orcid":false,"given":"Hiroki","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Urology Institute of Science Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2738-9792","authenticated-orcid":false,"given":"Masaki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Science Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4459-4384","authenticated-orcid":false,"given":"Shunya","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Science Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yudai","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Science Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shohei","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Science Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7548-1580","authenticated-orcid":false,"given":"Hiroshi","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Science Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9319-1373","authenticated-orcid":false,"given":"Yuma","family":"Waseda","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Science Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Science Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3632-2901","authenticated-orcid":false,"given":"Hajime","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Science Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2757-8083","authenticated-orcid":false,"given":"Soichiro","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Science Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6761-3229","authenticated-orcid":false,"given":"Yasuhisa","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Science Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Cancer Information Service NCCJ (National Cancer Registry Management of Health Labour and Welfare) \u201cCancer Statistics in 2020 [Internet] \u201d(2024) https:\/\/ganjoho.jp\/reg_stat\/statistics\/data\/dl\/index.html#a14."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-019-02707-9"},{"key":"e_1_2_11_4_1","unstructured":"P.Cornford D.Triantafyllou R. 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