{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:42:15Z","timestamp":1792204935179,"version":"4.4.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This collaborative, multi\u2010institutional retrospective study aimed to evaluate whether achieving the radical cystectomy\u2010pentafecta contributes to improved outcomes in patients with muscle\u2010invasive bladder cancer undergoing neoadjuvant chemotherapy followed by robot\u2010assisted radical cystectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 195 patients with muscle\u2010invasive bladder cancer who underwent robot\u2010assisted radical cystectomy with intracorporeal urinary diversion at four affiliated institutions. All had a minimum follow\u2010up of 12\u2009months. According to previously established criteria, patients who simultaneously demonstrated (i) negative soft tissue surgical margins, (ii) \u2265\u200916 lymph node yield, (iii) absence of major complications at 90\u2009days, (iv) absence of urinary diversion\u2010related long\u2010term sequelae, and (v) absence of clinical recurrence in the first year were considered to have achieved the radical cystectomy\u2010pentafecta.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The overall radical cystectomy\u2010pentafecta achievement rate was 46.2% (46.5% in the neoadjuvant chemotherapy group and 45.3% in the no chemotherapy group). In the neoadjuvant chemotherapy group, patients who achieved the radical cystectomy\u2010pentafecta demonstrated significantly better overall survival (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038), cancer\u2010specific survival (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009), and recurrence\u2010free survival (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) than those who did not.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The radical cystectomy\u2010pentafecta is a valuable tool to assess the quality of robot\u2010assisted radical cystectomy with intracorporeal urinary diversion. Its achievement may be associated with improved outcomes in patients with muscle\u2010invasive bladder cancer undergoing neoadjuvant chemotherapy prior to surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70283","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:35:49Z","timestamp":1762864549000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prognostic Significance of Achieving the Radical Cystectomy\u2010Pentafecta After Neoadjuvant Chemotherapy and Robot\u2010Assisted Radical Cystectomy"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6204-0866","authenticated-orcid":false,"given":"Kyotaro","family":"Fukuta","sequence":"first","affiliation":[{"name":"Department of Urology Tokushima Prefectural Central Hospital  Tokushima 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University Graduate School of Biomedical Sciences  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoichi","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Department of Urology Tokushima Prefectural Central Hospital  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Izaki","sequence":"additional","affiliation":[{"name":"Department of Urology Tokushima Prefectural Central Hospital  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8974-9218","authenticated-orcid":false,"given":"Junya","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Urology Tokushima University Graduate School of Biomedical Sciences  Tokushima 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