{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:39:49Z","timestamp":1792636789091,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Enfortumab vedotin (EV) has emerged as a key agent in the evolving treatment paradigm for metastatic urothelial carcinoma (UC). Although EV\u2010induced peripheral neuropathy (PN) occurs frequently, its risk factors and detailed clinical course remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter study included 115 consecutive patients with metastatic UC who were treated with EV monotherapy between 2021 and 2023. The incidence, risk factors, and clinical course of PN were analyzed retrospectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median age was 74\u2009years, and 85 (74%) were male. EV was initiated at a reduced dose of &lt;\u20091.25\u2009mg\/kg in 35 (30%) patients. PN occurred in 29 (25%) patients, with a cumulative incidence of 28% at 1\u2009year following EV induction. The maximum PN grades were 1, 2, and 3 in 9 (7.8%), 17 (15%), and 3 (2.6%) patients, respectively. The median time to PN onset was 2.7\u2009months. In multivariable analysis, higher serum albumin levels and starting EV at full\u2010dose were significantly associated with PN development. Of the patients who experienced Grade 1 PN and whose doses were maintained, 66.6% progressed to Grade 2 or higher. Of the patients who experienced Grade 2 PN and whose doses were maintained, 82% remained at Grade 2, while 18% ultimately progressed to Grade 3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher serum albumin levels were significantly associated with EV\u2010induced PN. Appropriate dose reduction may help prevent progression from Grade 2 to Grade 3 PN. Nevertheless, further prospective studies are warranted to determine the optimal dose management strategy for long\u2010term EV therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70329","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T06:31:11Z","timestamp":1766385071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical Features and Risk Factors of Enfortumab Vedotin\u2013Induced Peripheral Neuropathy in Patients With Metastatic Urothelial Carcinoma: A Multicenter Retrospective Study (\n                    <scp>YUSHIMA<\/scp>\n                    Study)"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7086-8214","authenticated-orcid":false,"given":"Takahiko","family":"Soma","sequence":"first","affiliation":[{"name":"Department of Urology Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  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