{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T02:09:10Z","timestamp":1769566150166,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>As the diagnostic efficacy and safety of magnetic resonance imaging (MRI)\u2013transrectal ultrasound (TRUS) fusion\u2010targeted transrectal biopsy for prostate cancer (PCa) detection have already been demonstrated when compared with those of conventional systematic biopsy, we aimed to further evaluate them.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective study, we included patients who underwent MRI\u2013TRUS fusion\u2010targeted transrectal biopsy combined with systematic biopsy between 2022 and 2024. The detection rates for overall and clinically significant PCa and adverse event (\u2265\u2009grade 3) rates were assessed. The results were compared with those of conventional systematic biopsies using propensity score matching.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In 223 patients who underwent MRI\u2013TRUS fusion biopsy combined with systematic biopsy (initial biopsy, 161; repeat biopsy, 62), the median prostate\u2010specific antigen level was 8.0\u2009ng\/mL; the median prostate volume was 35\u2009mL. The overall, clinically significant, and insignificant PCa detection rates were 67%, 60%, and 8%, respectively. After propensity score matching, detection rates were significantly higher in the MRI\u2013TRUS fusion group than in the control group for overall PCa (66% vs. 49%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005) and clinically significant PCa (58% vs. 41%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005), but were not significantly different for clinically insignificant PCa (8% vs. 8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091.000). The adverse event rate (\u2265\u2009grade 3) was not significantly different between the groups (3% vs. 3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091.000).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Compared with conventional biopsy, MRI\u2013TRUS fusion\u2010targeted transrectal biopsy combined with systematic biopsy could effectively detect clinically significant PCa without increasing detection of clinically insignificant PCa and adverse event rates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70334","type":"journal-article","created":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T07:05:47Z","timestamp":1766819147000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Magnetic Resonance Imaging\u2013Transrectal Ultrasound Fusion\u2010Targeted Biopsy Improves the Diagnostic Efficacy of Overall and Clinically Significant Prostate Cancer"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7989-5408","authenticated-orcid":false,"given":"Yusuke","family":"Fukiage","sequence":"first","affiliation":[{"name":"Department of Urology, Faculty of Medical Sciences University of Fukui  Eiheiji Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minekatsu","family":"Taga","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medical Sciences University of Fukui  Eiheiji Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahiro","family":"Inamura","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medical Sciences University of Fukui  Eiheiji Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimika","family":"Kaeriyama","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medical Sciences University of Fukui  Eiheiji Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medical Sciences University of Fukui  Eiheiji Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wonseok","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medical Sciences University of Fukui  Eiheiji Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Kakitsuba","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medical Sciences University of Fukui  Eiheiji Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahoko","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medical Sciences University of Fukui  Eiheiji Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nodoka","family":"Okubo","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medical Sciences University of Fukui  Eiheiji Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Kabuto","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medical Sciences University of Fukui  Eiheiji Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manami","family":"Tsutsumiuchi","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medical Sciences University of Fukui  Eiheiji 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1082-6089","authenticated-orcid":false,"given":"Naoki","family":"Terada","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medical Sciences University of Fukui  Eiheiji 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