{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:27:13Z","timestamp":1790083633625,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cytomegalovirus (CMV) infection remains a key opportunistic complication after kidney transplantation. We evaluated risk factors for CMV reactivation in a universal preemptive strategy for the recent patient cohort including immunologically crossmatch positive high\u2010risk recipients who underwent Intravenous Immunoglobulin (IVIG)\u2010based desensitization with rituximab (Rit).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this retrospective cohort study, 395 adult KTx recipients treated between 2019 and 2021 were enrolled. All 395 recipients were divided into 3 groups as follows: group 1 receiving IVIG (+)\/Rit (+),\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200932 (8.1%); group 2 Rit (+) only,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009270 (68.6%); group 3 receiving none,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200993 (23.5%). The purpose of this study is to examine the influence of immunosuppressants including IVIG and\/or Rit on CMV infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Totally, CMV antigenemia was observed in 51 of 395 recipients (12.9%). Among them, 8 out of 32 recipients in group 1 (25.0%) showed CMV antigenemia, 29 out of 270 recipients in group 2 (10.7%), and 14 out of 93 recipients in group 3 (15.1%). There was a higher tendency of CMV antigenemia incidence in group 1, compared to groups 2 and 3, although not statistical significance. Univariate and multivariate logistic regression identified pre\u2010transplant CMV\u2010IgG seronegativity (OR 2.58; 95% CI 1.36\u20134.88;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004) and Immunological high\u2010risk (OR 2.56; 95% CI 1.10\u20135.95;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038) as independent risk factors for CMV reactivation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Seronegative status and immunosuppression against high immunological risk increased reactivation risk. Prophylactic treatment could be useful to prevent postoperative early complication in highly sensitized recipients using IVIG.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70342","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T02:50:44Z","timestamp":1767840644000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Risk Assessment of Cytomegalovirus Reactivation After Kidney Transplantation Under a Universal Preemptive Strategy in the Era of Intravenous Immunoglobulin\u2010Based Desensitization Therapy"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5760-445X","authenticated-orcid":false,"given":"Yu","family":"Kijima","sequence":"first","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University  Tokyo 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