{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:54:40Z","timestamp":1790362480018,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the real\u2010world effectiveness and safety of apalutamide versus bicalutamide in combination with androgen deprivation therapy (ADT) for metastatic hormone\u2010sensitive prostate cancer (mHSPC) in Japanese clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This multicenter retrospective study analyzed 477 patients with mHSPC who received either apalutamide (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009102) or bicalutamide (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009375) in combination with ADT across 19 Japanese institutions. The primary outcome was time to castration\u2010resistant prostate cancer (CRPC). Secondary outcomes included overall survival (OS), prostate\u2010specific antigen (PSA) response, and adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The apalutamide group showed significantly higher CRPC\u2010free probability at 24\u2009months (68.2% vs. 39.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) compared to the bicalutamide group. While OS was similar between groups, the apalutamide group demonstrated superior PSA response at 3\u2009months (median PSA: 0.8 vs. 3.4\u2009ng\/mL) and lower requirement for secondary treatment (36.3% vs. 53.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). Adverse events were more frequent in the apalutamide group (30.4% vs. 4.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), particularly rash (15.7% vs. 0.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In real\u2010world Japanese clinical practice, apalutamide demonstrated superior efficacy in delaying progression to CRPC compared to bicalutamide when combined with ADT for mHSPC, with manageable safety profiles.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70369","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T08:27:02Z","timestamp":1771403222000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Real\u2010World Comparative Study of Apalutamide Versus Bicalutamide in Combination With Androgen Deprivation Therapy for Metastatic Hormone\u2010Sensitive Prostate Cancer"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0921-6308","authenticated-orcid":false,"given":"Hidetsugu","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Urology The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1044-912X","authenticated-orcid":false,"given":"Wataru","family":"Fukuokaya","sequence":"additional","affiliation":[{"name":"Department of Urology The Jikei 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