{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:28:19Z","timestamp":1789399699308,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In this study, we evaluated the efficacy of neoadjuvant chemo\u2010hormonal therapy before robot\u2010assisted radical prostatectomy in patients with very high\u2010risk prostate cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients with very high\u2010risk prostate cancer who underwent robot\u2010assisted radical prostatectomy with extended lymph node dissection at our hospital between January 2017 and September 2024 were included. We retrospectively compared the biochemical progression\u2010free survival rates between patients treated with (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922) and without (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200926) neoadjuvant chemo\u2010hormonal therapy. The neoadjuvant chemo\u2010hormonal therapy group received seven\u2010month hormonal therapy (androgen deprivation therapy plus bicalutamide) with 70\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      docetaxel (every three weeks over three cycles). Data were analysed using Easy R, Kaplan\u2013Meier method, log\u2010rank test, and Cox proportional hazards model (significance\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patient backgrounds showed significant inter\u2010group differences in age (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010) and initial prostate\u2010specific antigen levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), but not in clinical T stage (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.355), clinical N stage (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.081), biopsy Gleason score (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.485), or positive biopsy cores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.105). Despite the less favorable patient backgrounds in the neoadjuvant chemo\u2010hormonal therapy group, 3\u2010year biochemical progression\u2010free survival rates were significantly higher (70.6% vs. 35.3%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039). Using multivariate analysis, neoadjuvant chemo\u2010hormonal therapy significantly reduced biochemical recurrence (hazard ratio, 0.34; 95% confidence interval: 0.14\u20130.83,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Neoadjuvant chemo\u2010hormonal therapy before robot\u2010assisted radical prostatectomy resulted in favorable biochemical progression\u2010free survival rates in patients with very high\u2010risk prostate cancer. This result suggests that this therapeutic approach has potential for becoming a new standard of care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70387","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:01:58Z","timestamp":1772985718000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Neoadjuvant Chemo\u2010Hormonal Therapy on Reducing Recurrence in Patients With Very High\u2010Risk Prostate Cancer Undergoing Robot\u2010Assisted Radical Prostatectomy"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3427-7078","authenticated-orcid":false,"given":"Yuri","family":"Koyama","sequence":"first","affiliation":[{"name":"Division of Urology, Department of Surgery, Faculty of Medicine Tottori University  Tottori 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