{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:29:42Z","timestamp":1787671782452,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Sex cord\u2010stromal tumors (SCSTs) constitute approximately 5% of testicular malignancies. This investigation aimed to elucidate contemporary therapeutic approaches and clinical outcomes for patients with testicular SCSTs in Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participating institutions included Japan Clinical Oncology Group facilities, affiliated centers, and institutions with published cases. Clinical data and histopathological findings were compiled. Central pathological review involved representative tissue sections when available. Kaplan\u2013Meier methodology assessed recurrence\u2010free survival (RFS) and overall survival (OS). Stage I patients were stratified by cumulative pathological risk factors (tumor diameter \u2265\u20095\u2009cm, necrosis, moderate to severe nuclear atypia, lymphovascular invasion, infiltrative growth, and \u2265\u20093 mitoses per 10 high\u2010power fields).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 116 patients from 66 institutions, 112 met inclusion criteria. Histological distribution included Leydig cell (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200954), Sertoli cell (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200936), and other variants (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922). Twelve patients presented with metastatic disease; ten received systemic chemotherapy, with 20.8% five\u2010year OS. Among 91 stage I patients with follow\u2010up data, eleven developed recurrence. Patients with\n                      <jats:styled-content>&gt;<\/jats:styled-content>\n                      \u20092 risk factors demonstrated significantly inferior RFS compared with those showing \u2264\u20091 factor (26.4 versus 98.6% at 5\u2009years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Surgical intervention predominated in the recurrent cases (81.8%, 9\/11), while chemotherapy was administered to 45.5% (5\/11), and selected patients achieved prolonged disease control through repeated surgical resection without systemic therapy. OS rates were 90.9% and 50.5% at 5 and 10\u2009years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Patients with synchronous metastatic presentation demonstrated poor survival. Stage I patients with\n                      <jats:styled-content>&gt;<\/jats:styled-content>\n                      \u20092 pathological risk factors showed reduced RFS, with surgical management potentially efficacious for recurrent disease.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70399","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T05:26:57Z","timestamp":1773206817000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Current Treatment Patterns and Outcomes of Sex Cord Stromal Tumor Patients in Japan"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5468-7632","authenticated-orcid":false,"given":"Takashige","family":"Abe","sequence":"first","affiliation":[{"name":"Department of Urology Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Miyai","sequence":"additional","affiliation":[{"name":"Department of Basic Pathology National Defense Medical College  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4855-4366","authenticated-orcid":false,"given":"Toyonori","family":"Tsuzuki","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Aichi Medical University Hospital  Nagakute Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiyo","family":"Murai","sequence":"additional","affiliation":[{"name":"Department of Urology Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3031-7258","authenticated-orcid":false,"given":"Katsuyoshi","family":"Hashine","sequence":"additional","affiliation":[{"name":"Department of Urology National Hospital Organization Shikoku Cancer Center  Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Urology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6494-819X","authenticated-orcid":false,"given":"Takashi","family":"Kawahara","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naotaka","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Department of Urology University of Toyama  Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Department of Urology University of Toyama  Toyama 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