{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T16:10:50Z","timestamp":1789056650847,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013170","name":"Ono Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008021","name":"Bristol-Myers Squibb Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008021","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The J\u2010ENCORE study is a Japanese multicenter, prospective observational study involving patients with advanced or metastatic renal cell carcinoma treated with nivolumab\u2010plus\u2010ipilimumab combination as first\u2010line treatment. Interim 1\u2010 and 2\u2010year reports demonstrated efficacy and safety comparable to those of the CheckMate 214 trial, with sustained effects after nivolumab\u2010plus\u2010ipilimumab discontinuation, and explored outcome\u2010associated factors. This final analysis of a minimum 3\u2010year observation summarized long\u2010term outcomes, including real\u2010world second progression\u2010free survival and overall survival, and explored outcome\u2010associated factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Real\u2010world objective response rate, response duration, real\u2010world progression\u2010free survival, overall survival, treatment\u2010related adverse events, and real\u2010world second progression\u2010free survival were evaluated. Outcome\u2010associated factors were explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 274 patients (68.2% aged \u2265\u200965\u2009years; 42.0%, poor risk) from 37 sites, with a median follow\u2010up of 47.4 (range, 36.5\u201359.0) months. Real\u2010world objective response rate was 38.4%, with 30.5% maintaining \u2265\u200936\u2009months response duration. Median real\u2010world progression\u2010free survival and second progression\u2010free survival were 9.7 and 30.1\u2009months, respectively, and 60.2% of patients survived for \u2265\u200936\u2009months. Treatment\u2010related adverse events of any grade, grade 3\/4, and grade 5 occurred in 78.5%, 43.1%, and 1.1% of patients, respectively. No new treatment\u2010related adverse events or increased frequencies were reported since the previous interim analyses. Multivariable analyses identified associations between overall survival and age, lactate dehydrogenase levels, and C\u2010reactive protein levels, with favorable prognosis in patients with none or one of these factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We demonstrated long\u2010term real\u2010world outcomes of nivolumab\u2010plus\u2010ipilimumab. Our findings support prescriptions of nivolumab\u2010plus\u2010ipilimumab in real\u2010world clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trail Registration<\/jats:title>\n                    <jats:p>\n                      UMIN Clinical Trials Registry: UMIN000036772 and\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      : NCT04043975\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70400","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T09:47:24Z","timestamp":1773740844000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Minimum 3\u2010Year Follow\u2010Up of Nivolumab\u2010Plus\u2010Ipilimumab in Japanese Patients With Advanced or Metastatic Renal Cell Carcinoma: A Final Analysis of the J\u2010\n                    <scp>ENCORE<\/scp>\n                    Study"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9968-7468","authenticated-orcid":false,"given":"Shuzo","family":"Hamamoto","sequence":"first","affiliation":[{"name":"Department of Nephro\u2010Urology Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Nozawa","sequence":"additional","affiliation":[{"name":"Department of Urology Kindai University Faculty of Medicine  Sakai Japan"},{"name":"Department of Urology National Hospital Organization Osaka Minami Medical Center  Kawachinagano Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suguru","family":"Shirotake","sequence":"additional","affiliation":[{"name":"Department of Uro\u2010Oncology Saitama Medical University International Medical Center  Hidaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8902-7853","authenticated-orcid":false,"given":"Tomokazu","family":"Sazuka","sequence":"additional","affiliation":[{"name":"Department of Urology Graduate School of Medicine, Chiba University  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Numakura","sequence":"additional","affiliation":[{"name":"Department of Urology Akita University Graduate School of Medicine  Akita Japan"},{"name":"Department of Renal and Urologic Surgery Asahikawa Medical University  Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5643-2182","authenticated-orcid":false,"given":"Atsushi","family":"Mizokami","sequence":"additional","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology Graduate School of Medical Science, Kanazawa University  Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsunenori","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Adachi Medical Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6104-4344","authenticated-orcid":false,"given":"Sei","family":"Naito","sequence":"additional","affiliation":[{"name":"Department of Urology Yamagata University Faculty of Medicine  Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5468-7632","authenticated-orcid":false,"given":"Takashige","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Renal and Genitourinary Surgery Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2841-1998","authenticated-orcid":false,"given":"Kojiro","family":"Ohba","sequence":"additional","affiliation":[{"name":"Department of Urology Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Go","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Urology Nippon Medical School Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Urology Juntendo University Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunta","family":"Onodera","sequence":"additional","affiliation":[{"name":"Ono Pharmaceutical Co., Ltd.  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