{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T02:51:53Z","timestamp":1781751113887,"version":"3.54.5"},"reference-count":64,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":46,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Interstitial cystitis (IC) and bladder pain syndrome (BPS) have several clinical phenotypes. However, these subtypes may have similar symptoms, such as bladder pain, frequency, urgency, and functional somatic syndrome. A global consensus has been reached that bladders with characteristic Hunner's ulcer lesions are classified as IC, whereas those without Hunner's ulcer are classified as non\u2010ulcer IC\/BPS. To diagnose Hunner's IC, office cystoscopy without anesthesia is usually adequate for visualizing the presence of Hunner's lesions. However, the diagnostic accuracy of cystoscopic hydrodistention for non\u2010ulcer IC\/BPS has not been validated. Cystoscopic hydrodistention can detect mucosal dysfunction and chronic inflammation over long periods. Different grades of glomerulation may develop after hydrodistention of the bladder to a pressure of 80 cmH\n                    <jats:sub>2<\/jats:sub>\n                    O, and the maximal bladder capacity under anesthesia can be measured. The cystoscopic characteristics of IC\/BPS after hydrodistention are associated with bladder symptoms, bladder wall CT findings, inflammatory urine biomarkers, and histopathological findings in the bladder wall. Cystoscopic hydrodistention can be a useful diagnostic examination and a treatment for IC\/BPS. Cystoscopic findings are associated with severe bladder inflammation, clinical symptoms, and treatment outcomes.\n                  <\/jats:p>","DOI":"10.1111\/iju.70416","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:28:53Z","timestamp":1781659733000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Implications of Glomerulation After Cystoscopic Hydrodistention in Patients With Interstitial Cystitis and Bladder Pain Syndrome"],"prefix":"10.1111","volume":"33","author":[{"given":"Wan\u2010Ru","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Nursing Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation  Hualien Taiwan"},{"name":"Institute of Medical Sciences Tzu Chi University  Hualien Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010Hong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Urology Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University  Hualien Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Fong","family":"Jhang","sequence":"additional","affiliation":[{"name":"Department of Urology Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University  Hualien Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hann\u2010Chorng","family":"Kuo","sequence":"additional","affiliation":[{"name":"Institute of Medical Sciences Tzu Chi University  Hualien Taiwan"},{"name":"Department of Urology Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University  Hualien Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"issue":"9","key":"e_1_2_12_2_1","first-page":"2051","article-title":"The Pathomechanism and Current Treatments for Chronic Interstitial Cystitis and Bladder Pain Syndrome","volume":"12","author":"Yu W. 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