{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T02:52:10Z","timestamp":1781751130267,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":46,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The diagnosis of interstitial cystitis\/bladder pain syndrome primarily relies on symptom assessment and exclusion of other conditions, heavily depending on the physician's experience. Interstitial cystitis\/bladder pain syndrome is classified into two major categories: cases with Hunner lesions, while others without Hunner lesions. Detecting Hunner lesions requires cystoscopic examination; however, performing cystoscopy necessitates the physician suspecting that the patient is likely to have \u201cinterstitial cystitis\/bladder pain syndrome.\u201d Objective, non\u2010invasive biomarkers serving as diagnostic indicators are useful to suspect the disease. Although numerous studies have been conducted to identify useful biomarkers, clinical implementation has not yet been achieved. This paper reviews the current status of research on urine and serum biomarkers for interstitial cystitis\/bladder pain syndrome. Several promising biomarkers exist, but large\u2010scale, multi\u2010center studies to validate their reliability have not been conducted, and the path to clinical implementation remains long.<\/jats:p>","DOI":"10.1111\/iju.70421","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:16:46Z","timestamp":1781659006000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum and Urine Biomarkers for Interstitial Cystitis\/Bladder Pain Syndrome"],"prefix":"10.1111","volume":"33","author":[{"given":"Kazumasa","family":"Torimoto","sequence":"first","affiliation":[{"name":"Department of Urology Nara Prefecture General Medical Center  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Urology Ueda Clinic  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.14234"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000257"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/tcmj.tcmj_221_23"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.01.034"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-017-3547-5"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23431"},{"key":"e_1_2_9_8_1","article-title":"Clustering of Urinary Biomarkers to Identify Interstitial Cystitis Subtypes and Different Clinical Characteristics and Treatment Outcomes","volume":"13","author":"Tian J. 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