{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T02:34:03Z","timestamp":1788489243491,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K02769"],"award-info":[{"award-number":["25K02769"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Enfortumab vedotin (EV) is the standard treatment for locally advanced or metastatic urothelial carcinoma (la\/mUC), though skin toxicities are problematic. We evaluated whether prophylactic corticosteroid premedication is associated with reduced toxicity and survival outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively analyzed 157 patients with la\/mUC receiving EV monotherapy, stratified by prophylactic intravenous dexamethasone (6.6\u2009mg) premedication (pre\u2010EV steroid,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920) or not (no pre\u2010EV steroid,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009137). Endpoints included the incidence of EV\u2010related adverse events (AEs), objective response rate (ORR), progression\u2010free survival (PFS), and overall survival (OS). Inverse probability of treatment weighting (IPTW) was used to adjust for baseline imbalances.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Corticosteroid premedication was associated with a significantly lower incidence of skin AEs (10% vs. 62.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and a reduced number of cumulative AEs (median 1 vs. 2,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018). The ORR were comparable. However, patients with steroid premedication showed inferior OS compared to those without (median OS 10.3 vs. 17.4\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008), while PFS showed no significant difference. Multivariable analysis confirmed corticosteroid premedication as an independent predictor of reduced skin AEs (OR 0.08,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001); however, it was associated with worse OS (HR 1.91,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.048), with no significant impact on PFS. In the IPTW\u2010adjusted analysis, corticosteroid premedication remained significantly associated with worse OS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Corticosteroid premedication reduces skin toxicities during EV monotherapy, but its impact on survival remains uncertain and requires validation in larger studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70425","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T13:46:35Z","timestamp":1774273595000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of Prophylactic Intravenous Corticosteroid Premedication With Toxicity and Survival in Patients Receiving Enfortumab Vedotin for Locally Advanced or Metastatic Urothelial Carcinoma"],"prefix":"10.1111","volume":"33","author":[{"given":"Masanao","family":"Shinohara","sequence":"first","affiliation":[{"name":"Department of Urology Hirosaki University Graduate School of Medicine  Hirosaki Japan"},{"name":"Department of Urology Ageo Central General Hospital  Ageo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Urology Hirosaki University Graduate School of Medicine  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Kawashima","sequence":"additional","affiliation":[{"name":"Department of Urology Ageo Central General Hospital  Ageo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Sekine","sequence":"additional","affiliation":[{"name":"Department of Urology Akita University Graduate School of Medicine  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2988-1860","authenticated-orcid":false,"given":"Shintaro","family":"Narita","sequence":"additional","affiliation":[{"name":"Department of Urology Akita University Graduate School of Medicine  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Urology Asahikawa Medical University  Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Urology Asahikawa Medical University  Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5071-5149","authenticated-orcid":false,"given":"Hirotake","family":"Kodama","sequence":"additional","affiliation":[{"name":"Department of Urology Hirosaki University Graduate School of Medicine  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8284-9582","authenticated-orcid":false,"given":"Naoki","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Urology Hirosaki University Graduate School of Medicine  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3750-3811","authenticated-orcid":false,"given":"Teppei","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Urology Hirosaki University Graduate School of Medicine  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Numakura","sequence":"additional","affiliation":[{"name":"Department of Urology Asahikawa Medical University  Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of 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