{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:44:15Z","timestamp":1777571055371,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare the effectiveness and safety of two antibiotic prophylaxis regimens, ciprofloxacin plus gentamicin and ceftriaxone plus cefixime, in preventing infectious complications after transrectal ultrasound\u2010guided prostate biopsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The study retrospectively reviewed 705 consecutive patients who underwent transrectal ultrasound\u2010guided prostate biopsy between January 2020 and January 2024. Group 1 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009374) received ciprofloxacin plus gentamicin, and Group 2 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009331) received ceftriaxone plus cefixime. All patients underwent standard rectal preparation with povidone\u2010iodine, and needle\u2010tip disinfection with formalin. The primary outcome was the development of post\u2010biopsy infectious complications, while secondary outcomes included sepsis and infection\u2010related hospitalization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The two groups were comparable in terms of age, body mass index, prostate\u2010specific antigen levels, and comorbidities. The overall rate of post\u2010biopsy infection was 1.4%, occurring in 1.1% patients in Group 1 and 1.8% patients in Group 2 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.61). The incidence of complicated urinary tract infection was 0.3% versus 0.9%, and infection\u2010related hospitalization occurred in 0.5% versus 0.3% of patients in Group 1 and Group 2, respectively, with no cases of sepsis observed. In univariable analyses, diabetes mellitus, histopathological chronic prostatitis, and pre\u2010biopsy antibiotic use were not significantly associated with post\u2010biopsy infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The combination of ceftriaxone and cefixime showed a safety profile broadly consistent with the combination of ciprofloxacin and gentamicin for biopsy prophylaxis. Considering increasing fluoroquinolone resistance and growing restrictions, this cephalosporin\u2010based regimen may be considered a feasible option for transrectal ultrasound\u2010guided prostate biopsy when implemented together with strict antiseptic measures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70445","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T11:49:43Z","timestamp":1774612183000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of Infectious Complications After Transrectal Prostate Biopsy Under Two Antibiotic Prophylaxis Regimens: Ceftriaxone Plus Cefixime Versus Ciprofloxacin Plus Gentamicin"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8051-5802","authenticated-orcid":false,"given":"Ahmet Y\u0131ld\u0131r\u0131m","family":"Bal\u0131k","sequence":"first","affiliation":[{"name":"Department 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