{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T09:55:45Z","timestamp":1781862945368,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100005565","name":"Johnson & Johnson Innovative Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005565","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008719","name":"Movember Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008719","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Accurate Gleason grading is crucial for prostate cancer (PCa) treatment decisions; incorrect assessment can lead to under\u2010 or overtreatment; discordance between biopsy and radical prostatectomy (RP) grades is a marker of this inaccuracy. Using the Irish Prostate Cancer Outcomes Research (IPCOR) cohort, we sought to quantify Gleason grade concordance, upgrading, and downgrading trends in PCa RP patients, assess the impact of pre\u2010biopsy MRI on diagnostic accuracy, and compare Irish trends with international findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A contextual literature review summarized international regrading rates. IPCOR enrolled 6816 men diagnosed with PCa. We included 1194 men who underwent both biopsy and RP within 180\u2009days. Biopsy and RP Gleason Grade Groups (GG) were compared to estimate concordance, upgrading, and downgrading. Sub\u2010analyses examined regrading by biopsy modality and pre\u2010biopsy MRI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall concordance was 57.0%, similar international median of 52.9%. Concordance was lowest for GG1 (32.7%) and highest for GG2 (74.8%), while higher GGs showed frequent downgrading (GG4 46.8%; GG5 33.3%). Among men with TRUS biopsy, pre\u2010biopsy MRI was associated with higher concordance (59.8% vs. 55.8%) and lower upgrading (19.3% vs. 29.4%), though differences were not statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Gleason regrading patterns in Ireland mirror global experience, with upgrading in lower and downgrading in higher GGs. Pre\u2010biopsy MRI shows a favorable trend toward improved diagnostic accuracy, supporting its integration into clinical pathways.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70469","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:23:47Z","timestamp":1777379027000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gleason Regrading After Prostatectomy\u2014Results From the Irish Prostate Cancer Outcome Research (\n                    <scp>IPCOR<\/scp>\n                    ) Situated in the International Context"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8187-6634","authenticated-orcid":false,"given":"Noa","family":"Gordon","sequence":"first","affiliation":[{"name":"UCD School of Medicine and UCD Conway Institute University College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayush Amish","family":"Patel","sequence":"additional","affiliation":[{"name":"UCD School of Medicine and UCD Conway Institute University College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wasfa","family":"Farooq","sequence":"additional","affiliation":[{"name":"UCD School of Medicine and UCD Conway Institute University College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Watson","sequence":"additional","affiliation":[{"name":"UCD School of Medicine and UCD Conway Institute University College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Galvin","sequence":"additional","affiliation":[{"name":"UCD School of Medicine and UCD Conway Institute University College Dublin  Dublin Ireland"},{"name":"St Vincent's University Hospital  Dublin Ireland"},{"name":"Mater Misericordiae University Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"J.Ferlay M.Ervik F.Lam et\u00a0al. \u201cCancer Today \u201d(2024) https:\/\/gco.iarc.who.int\/today\/."},{"key":"e_1_2_13_3_1","volume-title":"Cancer in Ireland 1994\u20102022: Annual Statistical Report of the National Cancer Registry","author":"National Cancer Registry Ireland","year":"2024"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.10.046"},{"key":"e_1_2_13_5_1","unstructured":"National Cancer Control Programme \u201cHSE National Clinical Guideline: Active Surveillance for Patients With Prostate Cancer \u201d(2025) https:\/\/www2.healthservice.hse.ie\/organisation\/national\u2010pppgs."},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prnil.2016.07.004"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12894\u2010019\u20100526\u20109"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13179"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.05.059"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2019.00055"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2019.08.001"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/rycan.2021200123"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910038"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102024\u2010090207"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath\u20102014\u2010202767"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1677\u20105538.IBJU.2017.0552"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345\u2010019\u201002634\u20109"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2020.1996"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2019.07.049"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/03915603221118457"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.purol.2023.01.004"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2020.153235"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41391\u2010023\u201000714\u2010x"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.4081\/aiua.2022.3.278"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2023.02.001"},{"key":"e_1_2_13_27_1","unstructured":"EAU \u2010 EANM \u2010 ESTRO \u2010 ESUR \u2010 ISUP \u2010 SIOG \u201cProstae Cancer Guidelines. Presented at the EAU Annual Congress Paris 2024\u201d."},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000003492"},{"key":"e_1_2_13_29_1","unstructured":"\u201cHSE National Clinical Guideline: Diagnosis and Staging of Patients With Prostate Cancer \u201d(2022) https:\/\/www2.healthservice.hse.ie\/organisation\/national\u2010pppgs\/national\u2010clinical\u2010guideline\u2010diagnosis\u2010and\u2010staging\u2010of\u2010patients\u2010with\u2010prostate\u2010cancer\/."},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/clinpract14020039"}],"container-title":["International Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.70469","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iju.70469","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.70469","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T09:24:04Z","timestamp":1781861044000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iju.70469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/iju.70469"],"URL":"https:\/\/doi.org\/10.1111\/iju.70469","archive":["Portico"],"relation":{},"ISSN":["0919-8172","1442-2042"],"issn-type":[{"value":"0919-8172","type":"print"},{"value":"1442-2042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,28]]},"assertion":[{"value":"2025-12-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70469"}}