{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:56:09Z","timestamp":1791687369930,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K09477"],"award-info":[{"award-number":["22K09477"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Periprostatic adipose tissue (PPAT) is increasingly recognized as a component of the prostate cancer (PCa) microenvironment. However, the role of uncoupling protein 1 (UCP1) in PPAT remains unclear. We investigated the association between PCa grade and UCP1 expression in PPAT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      After institutional review board approval, we collected PPAT and abdominopelvic adipose tissue (APAT) samples from 83 Japanese patients who underwent robot\u2010assisted radical prostatectomy for clinically localized PCa.\n                      <jats:italic>UCP1<\/jats:italic>\n                      mRNA expression in PPAT was quantified by RT\u2010qPCR and normalized to APAT expression (PPAT\/APAT ratio). PPAT volume was estimated by computed tomography. Associations with pathological stage and International Society of Urological Pathology (ISUP) grade were evaluated, and logistic regression was performed to identify factors associated with high\u2010grade disease (ISUP 4\/5).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the univariable logistic regression analysis, lower (log\u2010transformed)\n                      <jats:styled-content style=\"fixed-case\">UCP1<\/jats:styled-content>\n                      expression was significantly associated with high\u2010grade\n                      <jats:styled-content style=\"fixed-case\">PCa<\/jats:styled-content>\n                      (\n                      <jats:styled-content style=\"fixed-case\">ISUP<\/jats:styled-content>\n                      4\/5) (odds ratio [\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      ] 0.415, 95% confidence interval [\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      ] 0.180\u20130.883,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027). Age, prostate serum antigen (\n                      <jats:styled-content style=\"fixed-case\">PSA<\/jats:styled-content>\n                      ) concentration, and\n                      <jats:styled-content style=\"fixed-case\">PPAT<\/jats:styled-content>\n                      volume were not significantly associated with high\u2010grade disease. In the multivariable analysis adjusted for age,\n                      <jats:styled-content style=\"fixed-case\">PSA<\/jats:styled-content>\n                      concentration, and\n                      <jats:styled-content style=\"fixed-case\">PPAT<\/jats:styled-content>\n                      volume,\n                      <jats:styled-content style=\"fixed-case\">UCP1<\/jats:styled-content>\n                      expression remained independently associated with high\u2010grade\n                      <jats:styled-content style=\"fixed-case\">PCa<\/jats:styled-content>\n                      (\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      0.438, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      0.188\u20130.945,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.035). No other clinicopathological variables demonstrated independent associations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Reduced UCP1 expression in PPAT was independently associated with high\u2010grade PCa. PPAT UCP1 expression may represent a microenvironment\u2010associated marker reflecting PCa severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70506","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T18:26:33Z","timestamp":1779301593000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Reduced Uncoupling Protein 1 Expression in Periprostatic Adipose Tissue and Its Association With Higher Prostate Cancer Grade"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9424-3764","authenticated-orcid":false,"given":"Eiji","family":"Kashiwagi","sequence":"first","affiliation":[{"name":"Department of Urology, Graduate School of Medical Science Kyushu University  Fukuoka Japan"},{"name":"Department of Urology, School of Medicine University of Occupational and Environmental Health  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miho","family":"Ushijima","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medical Science Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medical Science Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuto","family":"Tsubonuma","sequence":"additional","affiliation":[{"name":"Department of Urology, School of Medicine University of Occupational and Environmental Health  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yui","family":"Mizushima","sequence":"additional","affiliation":[{"name":"Department of Urology, School of Medicine University of Occupational and Environmental Health  Kitakyushu 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