{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T13:36:17Z","timestamp":1781962577813,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Penile cancer is a rare malignancy, and multicenter data evaluating prognostic biomarkers in the Japanese population are limited. This study aimed to assess the prognostic significance of pretreatment blood\u2010based biomarkers in patients with penile cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a multicenter retrospective cohort study including 111 patients with penile cancer treated between January 2005 and December 2023 at ten institutions participating in the West Japan Uro\u2010oncology Collaboration Group. Cancer\u2013specific survival (CSS) was analyzed using the Kaplan\u2013Meier method and Cox proportional hazards model. Receiver operating characteristic analyses were performed to determine optimal cutoff values for the neutrophil\u2010to\u2010lymphocyte ratio (NLR), platelet\u2010to\u2010lymphocyte ratio (PLR), and squamous cell carcinoma antigen (SCC\u2010Ag). A composite biomarker score was calculated based on the number of elevated biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The 5\u2010year overall survival and CSS rates were 71.1% and 77.4%, respectively. In univariate analyses, elevated PLR, elevated SCC\u2010Ag, and higher composite biomarker scores were significantly associated with poorer CSS. In multivariate analysis, advanced clinical nodal status (\u2265 cN2) and distant metastasis (cM1) remained independent predictors of CSS, whereas blood\u2010based biomarkers did not retain independent prognostic significance after adjustment for established clinicopathological factors. Kaplan\u2013Meier analyses demonstrated significantly worse CSS in patients with high PLR, high SCC\u2010Ag levels, and higher composite biomarker scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pretreatment blood\u2010based biomarkers, particularly PLR and SCC\u2010Ag, are associated with prognosis in penile cancer. Although they did not retain independent prognostic factors after adjustment, these biomarkers may provide complementary prognostic information and help identify high\u2010risk patients in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70507","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T18:18:03Z","timestamp":1779301083000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prognostic Significance of Pretreatment Blood\u2010Based Biomarkers in Penile Cancer: A Multicenter Retrospective Study in Japan"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4224-5084","authenticated-orcid":false,"given":"Shuichi","family":"Tatarano","sequence":"first","affiliation":[{"name":"Department of Urology, Graduate School of Medical and Dental Sciences Kagoshima University  Kagoshima 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Urology, Faculty of Medicine Osaka Medical and Pharmaceutical University  Takatsuki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2098-3916","authenticated-orcid":false,"given":"Kohei","family":"Kobatake","sequence":"additional","affiliation":[{"name":"Department of Urology Hiroshima University Graduate School of Biomedical and Health Sciences  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikiya","family":"Taoka","sequence":"additional","affiliation":[{"name":"Department of Urology Kagawa University Faculty of Medicine  Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junya","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Urology Tokushima University Graduate School of Biomedical Sciences  Tokushima 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