{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T21:30:17Z","timestamp":1785101417556,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The ENABLE study, an investigator\u2010initiated, multicenter, randomized controlled trial, demonstrated comparable survival benefits between enzalutamide (ENZ) and abiraterone plus prednisolone (ABI) for castration\u2010resistant prostate cancer (CRPC). Because randomized controlled trials typically exclude patients with a history of other cancers (HOCs), we evaluated the efficacy of these agents in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This sub\u2010analysis was conducted as a post hoc analysis using data from the ENABLE study. Endpoints included time to PSA progression, radiographic progression\u2010free survival, overall survival (OS), prostate cancer\u2010specific survival, and safety. Outcomes were compared between patients with and without a HOC+ versus HOC\u2212 and between treatment arms within each group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The HOC+ group included 35 patients (13 ENZ, 22 ABI), whereas the HOC\u2212 group included 149 patients (79 ENZ, 70 ABI). The most frequent malignancy was gastric cancer (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910, 29%). HOC+ patients had significantly worse OS than HOC\u2212 patients (median 24.7 vs. 37.4\u2009months; HR 1.96; 95% CI 1.02\u20133.77;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0426), while other survival endpoints did not differ between the groups. Within the HOC+ group, OS was significantly worse with ENZ than with ABI (median 16.0 vs. 30.5\u2009months; HR 3.27; 95% CI 1.08\u20139.89;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0354), whereas no significant differences were observed between the arms in the HOC\u2212 group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although OS was poorer in HOC+ patients, other outcomes were similar, supporting the feasibility of ENZ and ABI regardless of cancer history. The longer OS with ABI in HOC+ patients represents a hypothesis\u2010generating observation and should be interpreted with particular caution.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70511","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T23:55:24Z","timestamp":1779321324000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and Safety of Enzalutamide and Abiraterone in\n                    <scp>CRPC<\/scp>\n                    Patients With a History of Other Cancers: A Sub\u2010Analysis of the\n                    <scp>ENABLE<\/scp>\n                    Study for\n                    <scp>PCa<\/scp>"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1545-1827","authenticated-orcid":false,"given":"Seiji","family":"Hoshi","sequence":"first","affiliation":[{"name":"Department of Urology Fukushima Medical University School of Medicine  Fukushima Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouji","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science  Kanazawa Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Meguro","sequence":"additional","affiliation":[{"name":"Department of Urology Fukushima Medical University School of Medicine  Fukushima Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Shima","sequence":"additional","affiliation":[{"name":"Department of Urology Toyama Prefectural Central Hospital  Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1833-5381","authenticated-orcid":false,"given":"Yuki","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Urology Fukui\u2010ken Saiseikai Hospital  Fukui Fukui Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Mita","sequence":"additional","affiliation":[{"name":"Department of Urology Hiroshima City North Medical Center Asa Citizens Hospital  Hiroshima Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiko","family":"Okamura","sequence":"additional","affiliation":[{"name":"Department of Urology Anjo Kosei Hospital  Anjo Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Urology Kobatake Hospital  Fukuyama Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4224-5084","authenticated-orcid":false,"given":"Shuichi","family":"Tatarano","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medical and Dental Sciences Kagoshima University  Kagoshima Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9242-7877","authenticated-orcid":false,"given":"Nobumichi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Urology Nara Medical University  Kashihara Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Yoshio","sequence":"additional","affiliation":[{"name":"Nephro\u2010Urologic Surgery and Andrology Mie University Graduate School of Medicine  Tsu Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Kamiyama","sequence":"additional","affiliation":[{"name":"Department of Urology University of Yamanashi Graduate School of Medical Sciences  Chuo Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ippei","family":"Chikazawa","sequence":"additional","affiliation":[{"name":"Department of Urology Kanazawa Medical University 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