{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T05:47:54Z","timestamp":1782452874630,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We assessed the efficacy of testosterone replacement therapy (TRT) combined with exercise on body composition in hypogonadal men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Two hundred\u2010fourteen patients were enrolled. All patients were divided into four groups: patients with exercise habits who received TRT (T\u2009+\u2009E group;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200959), those without exercise habits who received TRT (T group;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200952), those with exercise habits who did not receive TRT (E group;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200957), those without exercise and TRT (control group;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200946). Exercise habits were defined as performing any exercises for 30\u2009min or more at least twice a week. TRT was administered via intramuscular testosterone enanthate (250\u2009mg) injection for one year. Data on age, current medical histories, and comorbidities were collected. Height, weight, body fat percentage, body mass index, lean body mass (LBM), waist circumference, and fat\u2010free mass index (FFMI) were measured at the initial visit, as well as 6 and 12\u2009months after the initiation of medical interventions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients in the T group were significantly younger and had significantly higher free testosterone levels than those in the other groups. In the T\u2009+\u2009E group, body fat percentage significantly decreased at the 6\u2010month visit. A significant increase in LBM and FFMI was observed at 6 and 12 months after TRT initiation in this group, whereas these parameters did not show significant improvement in the other three groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TRT for one year contributed to significant increases in LBM and FFMI among hypogonadal men with exercise habits, although no significant improvement was observed with exercise or TRT alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70524","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T06:49:23Z","timestamp":1779950963000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Testosterone Replacement Therapy Combined With Exercise on Body Composition in Hypogonadal Men"],"prefix":"10.1111","volume":"33","author":[{"given":"Kazuyoshi","family":"Shigehara","sequence":"first","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science  Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rei","family":"Shinzawa","sequence":"additional","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science  Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoaki","family":"Sakatoku","sequence":"additional","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science  Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9792-2068","authenticated-orcid":false,"given":"Takahiro","family":"Nohara","sequence":"additional","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science  Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouji","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science  Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikio","family":"Namiki","sequence":"additional","affiliation":[{"name":"Department of Urology Hasegawa Hospital  Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Mizokami","sequence":"additional","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science  Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.5114\/pm.2017.68595"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ22-0604"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2014.0500226"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11206202"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2019.01.006"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa917"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12126"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2012.09.016"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13225"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2008.02203.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/52.6.953"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/63.9.984"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13473"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2020.111106"},{"key":"e_1_2_11_16_1","first-page":"583","article-title":"Effects of Testosterone Supplementation for 3\u2009Years on Muscle Performance and Physical Function in Older Men","volume":"102","author":"Storer T. 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