{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T09:54:43Z","timestamp":1781862883628,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Desmopressin is an established treatment for nocturia due to nocturnal polyuria. In Japan, low\u2010dose formulations (25 and 50\u2009\u03bcg) were approved only for men in 2019. However, age\u2010 and dose\u2010specific prescribing patterns in real\u2010world practice remain unclear. Using nationwide aggregated claims data, we analyzed age\u2010stratified prescribing trends and dose selection patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Publicly available NDB Open Data (fiscal years 2020\u20132023) were used. Outpatient prescriptions for desmopressin orally disintegrating tablets (25 and 50\u2009\u03bcg) were extracted by sex and 5\u2010year age categories. Population\u2010adjusted prescription rates per 1000 persons and 95% confidence intervals (CIs) were calculated. Temporal trends were evaluated using Poisson regression models with log\u2010population offset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In men, the population\u2010adjusted prescription rate increased from 21.5 per 1000 persons in 2020 to 84.6 in 2023 (\n                      <jats:italic>p<\/jats:italic>\n                      for trend &lt;\u20090.001). More than 90% of prescriptions were issued to individuals aged \u2265\u200965\u2009years. Overall, use of the 25 and 50\u2009\u03bcg formulations was balanced; however, the proportion of the 25\u2009\u03bcg formulation increased with advancing age, and the 25\u2009\u03bcg\/50\u2009\u03bcg ratio reached 1.37 among those aged \u2265\u200990\u2009years. Prescriptions in women also increased, with predominance of the 25\u2009\u03bcg formulation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Desmopressin prescribing has increased nationwide in Japan, particularly among older men. Increased selection of the lower\u2010dose formulation in older patients may reflect safety considerations. Off\u2010label use in women is increasing, indicating the need for further safety evaluation and appropriate prescribing guidelines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.70527","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T07:45:57Z","timestamp":1779695157000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nationwide Trends in Desmopressin Prescribing for\u00a0Nocturnal Polyuria in Japan: A Population\u2010Based Analysis (2020\u20132023)"],"prefix":"10.1111","volume":"33","author":[{"given":"Kenichi","family":"Sasaki","sequence":"first","affiliation":[{"name":"Department of Urology Kyorin University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2552-1964","authenticated-orcid":false,"given":"Motofumi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Urology Mishima General Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Urology Kyorin University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamasa","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Urology Kyorin University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiyasu","family":"Horikawa","sequence":"additional","affiliation":[{"name":"Department of Urology Kyorin University School of Medicine  Tokyo 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1813-3090","authenticated-orcid":false,"given":"Mitsuhiro","family":"Tambo","sequence":"additional","affiliation":[{"name":"Department of Urology Kyorin University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Fukuhara","sequence":"additional","affiliation":[{"name":"Department of Urology Kyorin University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10053"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2009.03.080"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/luts.12229"},{"key":"e_1_2_11_5_1","volume-title":"Review Report of Desmopressin Orally Disintegrating Tablet for 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